Page 109 - COMMUNITY PHARMACY PRACTICE
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02/04/2024
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Why not with local aminoglycoside antibiotics?
• Neomycin and possibly other anti-infective agents eliminate certain
colonic bacteria & this may interfere with the desired degradation of
lactulose (into lactic acid)and thus prevent the acidification of colonic
contents.
• BUT combination could work in some cases: reports that lactulose
fermenting bacteria are relatively resistant to neomycin
• Monitoring required in the event of concomitant oral antibiotic therapy
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