Page 129 - COMMUNITY PHARMACY PRACTICE
P. 129
02/04/2024
262
(pathophysiology)
According to mechanism
• Osmotic
• Secretory
• Exudative
• motor
262
263
Osmotic diarrhea:
Occurs when a nonabosrbable solute pulls excess water into the
intestinal tract
• Ingestion of large meals or certain osmotic substances (e.g., sorbitol
and glycerin) can lead to diarrhea.
• Disaccharidase deficiency: It is a lack of enzymes needed to
break down disaccharides in the gut for absorption (lactase
deficiency) resulting in an increase in osmotic sugars as lactose
and sucrose in the intestinal tract.
• Medications that induce osmotic diarrhea include lactulose and
magnesium containing antacids and laxatives.
263
131