Page 130 - COMMUNITY PHARMACY PRACTICE

02/04/2024

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Secretory diarrhea:

• Occurs when the intestinal wall is damaged, resulting in
an increased secretion rather than absorption of
electrolytes into the intestinal tract.

• Common sources include: -

• Bacterial endotoxins E. coli- v. cholerae- shigella - s. aureus.

• Bacterial infectionsShigella -salmonella
• Viral infections Rotavirus - Norwalk virus

• Protozoal infectionsGiardia lambila - Entamoeba histolytica
• Miscellaneous IBS,
• Medications (prostaglandins, antibiotics, colchicine and

chemotherapy)

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Motility disorders (Motor)

• Results in decreased contact time of the fecal
mass with the intestinal wall so less water is
absorbed from the faeces.

• Motility disorders include: IBS, diabetic neuropathy
and gastric/intestinal resection.

• Medications induce motility disorders: …next slides

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