Page 202 - COMMUNITY PHARMACY PRACTICE

02/04/2024

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FIRST GENERATION NSAIDS:

¨ These have been used for many years as
analgesics, antipyretic and anti-inflammatories.

¨ They are non-selective inhibitors of cyclo-
oxigenase (COX) enzyme responsible for formation
of important biological mediators called :
prostaglandins, prostacyclin and thromboxane.

¨ At present ,three COX isoenzymes are known:
COX-1, COX-2 and COX-3.

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COX-1 inhibition 409

• Prostaglandins serve a protective role, preventing the
stomach mucosa from being eroded by its own acid.

• When nonselective cox-1/cox-2 inhibitors (such as
aspirin, ibuprofen, and naproxen) lower stomach
prostaglandin levels, these protective effects are lost
and ulcers of the stomach or duodenum and potentially
internal bleeding can result.

Main side effects of NSAID s

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