Page 38 - phytotherapy_ EBOOK_2025

patients suffering from intestinal obstruction, stenosis, or atony, as well as in those with
severe dehydration accompanied by electrolyte imbalance or chronic constipation.
Aloe should not be administered to patients with inflammatory bowel conditions, including
appendicitis, Crohn’s disease, ulcerative colitis, or irritable bowel syndrome, nor should
it be given to children under 10 years of age.
Its use is not recommended during pregnancy or lactation unless prescribed and closely
supervised by a qualified healthcare provider after careful assessment of potential risks and
benefits.
Furthermore, Aloe is contraindicated in individuals experiencing abdominal cramps, colic,
haemorrhoids, nephritis, or undiagnosed gastrointestinal symptoms such as pain,
nausea, or vomiting.
Warnings
Aloe-based laxatives should be used only when dietary modifications or bulk-forming
agents fail to produce the desired effect.
They must not be used in the presence of abdominal pain, nausea, or vomiting, as these
symptoms may indicate a serious underlying condition.
If rectal bleeding occurs or bowel movement fails to occur within 24 hours of
administration, medical evaluation is warranted.
Prolonged or habitual use can result in dependence, requiring progressively higher doses,
as well as electrolyte disturbances (notably hypokalaemia) and the development of an
atonic colon with reduced bowel function.
Use for more than two weeks should occur only under medical supervision.
Chronic misuse leading to persistent diarrhoea and electrolyte loss may cause albuminuria,
haematuria, and cardiac or neuromuscular complications, especially when combined with
cardiac glycosides (e.g., digoxin), diuretics, corticosteroids, or liquorice root.

Precautions
Laxatives containing anthraquinone glycosides should not be used continuously for longer
than 1–2 weeks, as prolonged use increases the risk of electrolyte imbalance.

Drug Interactions

Acceleration of intestinal transit caused by Aloe may reduce the absorption of orally

administered drugs.

Hypokalaemia resulting from prolonged laxative abuse may enhance the effects of

cardiotonic glycosides (such as digitalis) and antiarrhythmic agents (e.g., quinidine).

Concomitant use of thiazide diuretics, adrenocorticosteroids, or liquorice root can

intensify potassium depletion and further aggravate electrolyte disturbances.

37