Page 165 - Pharm.Org.Chem I 05-PC101 (1)
P. 165

Halogenation

• Overall reaction:

• Mechanism:
• Step 1: generation of the electrophile (Chloronium

 ion)

2025-026  Dr. Marwa El-Wakil                          27

• Step 2: attack of the chloronium ion on the ring

Step 3: proton ejection regenerates aromaticity of the ring

2025-026  Dr. Marwa El-Wakil                          28

                                                               163
   160   161   162   163   164   165   166   167   168   169   170