Page 166 - Pharm.Org.Chem I 05-PC101 (1)
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Useful links
• Nitration of benzene: https://www.youtube.com/watch?v=-
aGVvXgDvhA
• Chlorination of benzene:
https://www.youtube.com/watch?v=rcxAvtErMWs
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Friedel-Crafts Alkylation
• The reaction involves introducing an alkyl group to the
benzene ring.
• This is done by reacting benzene with alkyl halide (RX) in
presence of AlX3, where X = Cl, Br, I.
• The reaction was named after the 2 scientists:
Charles Friedel James Mason Crafts
• Overall reaction:
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