Page 149 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book

Pharm D- Clinical Pharmacy Program Third Level Pharmaceutical Microbiology& Antimicrobials (PM 502)

Cell Membrane

1- Polyene

• Polyene antibiotics are characterized by possessing a large ring containing a
lactone group and a hydrophobic region consisting of a sequence of four to seven
conjugate double bonds.

• The only important polyenes are amphotericin B and nystatin.

Mechanism of action:
Act by binding to ergosterol in the fungal cell membrane

Formation of pores

Increase permeability to proteins and
monovalent and divalent cations

Cell death.

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