Page 154 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book
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Pharm D- Clinical Pharmacy Program Third Level Pharmaceutical Microbiology& Antimicrobials (PM 502)
Nucleic acid Synthesis
Flucytosine
Mechanism of action:
absorbed into fungal cells
via cytosine permease.
converted to 5-
fluorouracil
interferes with fungal
RNA biosynthesis
Use:
• a narrow -spectrum antifungal agent
• Treats systemic Candida spp. or Cryptococcus spp.
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