Page 155 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book
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Pharm D- Clinical Pharmacy Program        Third Level          Pharmaceutical Microbiology& Antimicrobials (PM 502)



                                                       Fungal cell mitosis





                  Griseofulvin




                  Mechanism of action: a mitotic inhibitor


                            binds to polymerized
                            fungal microtubules.





                              inhibiting the de-

                               polymerization




                            failure of the fungal

                               cell replication



                  Use:
                         •  Oral agent and is indicated for the treatment of dermatophytosis of the


                             skin, hair, and nails. Ex: Tinea














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