Page 151 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book
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Pharm D- Clinical Pharmacy Program Third Level Pharmaceutical Microbiology& Antimicrobials (PM 502)
2- Azoles
The azoles may be considered as two subgroups:
➢ Imidazole (the older drugs)
➢ Trialzole (the newer drugs)
Mechanism of action:
blocking the demethylation
of lanosterol to ergosterol
Accumulation of toxic
intermediate sterols
Increased membrane
permeability, cell death
Imidazole
Clotrimazole Miconazole Ketoconazole Econazole
• Majority are used as topical products
• Used for the treatment of superficial infections by
➢ Dermatophytes (skin pathogens)
➢ Pityriasis species (causing flaky skin and dandruff)
➢ Candida albicans
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