Page 152 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book

Pharm D- Clinical Pharmacy Program Third Level Pharmaceutical Microbiology& Antimicrobials (PM 502)

Triazoles

Fluconazole Itraconazole Posaconazole Voriconazole

• All four of the triazole drugs are orally active

• All Except Posaconazole are available in injection form.

• Fluconazole is better absorbed from GIT than itraconazole

• Itraconazole is more frequently associated with liver toxicity than

fluconazole.

Use: (As imidazole) treatment of dermatophytes, pityriasis and Candida

infections

3- Allylamines

Mechanism of action:
Inhibit the enzyme squalene epoxidase, responsible for synthesizing precursors to
ergosterol

Accumulation of toxic
squalene

Lack of ergosterol, loss
of cell membrane
integrity

cell lysis

Terbinafine
• can be administered topically or orally, which is dependent on the fungal

infection being local or systemic

Use: treatment of tinea infections (Ringworms)

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