Page 35 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book

Pharm D- Clinical Pharmacy Program Third Level Pharmaceutical Microbiology& Antimicrobials (PM 502)

• require longer duration, extended to several hours, for the sterilization of relatively
large masses

• known as a ‘Cold Process,’ as the temperature of the processed product does not
increase significantly

• Materials which are sterilized using this type of radiation do not become
radioactive

• Used for sterilization of

- Plastic syringes, Hypodermic - Thermolabile medicaments
needles
- Surgical gloves, Gowns, masks - Human tissue grafts (Bone,
cartilage, Heart valve, skin)

- Sticking plasters, Dressings - Food sterilization
- (fruits, vegetables, meats)

Advantages: Have a high penetration power so materials can be sterilized after
filling them in the final container

Disadvantages:

➢ Undesirable changes in medicine such as color, solubility and texture of the
product
➢ Does not change nutritional value. But the flavor of the food is often spoiled

➢ Expensive

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