Page 73 - MNU-PM502- Pharmaeutical Microbiology Theoritical Book

Pharm D- Clinical Pharmacy Program Third Level Pharmaceutical Microbiology& Antimicrobials (PM 502)

2- Chemical indicators
• Uses sensitive chemicals that change color when exposed to high
temperatures or combinations of time and temperature.
• Chemical indicators are single-parameter and multiparameter.

• These can be external or internal indicators
• ISO 11140-1:2014 classifies chemical indicators for autoclaves and
sterilizers as follows

Class What They indicate Application Example

Class1 : Indicates if the item has • Autoclave tape
Process been exposed to a • chemical indicator strips
sterilization process Located attached to the outside of
packs

Class 2 : Test air removal in Bowie-Dick test packs
Specific-Use sterilization cycle

Class 3 : One critical variable in Chemical pellet
Single-Variable the sterilization process Melts at a specified temperature
(time or temperature.)

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