Page 5 - High Alert Medications INFORMATICS_Neat

C. Contraindication:

1. Hypersensitivity to drug

2. Angle-closure glaucoma

3. Cardiac dilatation, cardiac insufficiency

4. Cerebral arteriosclerosis, organic brain syndrome

D. Side effects:

1. CNS: nervousness, anxiety, tremor, vertigo, headache, disorientation, agitation,
drowsiness, fear, dizziness, cerebral haemorrhage, cerebrovascular accident (CVA)

2. CV: palpitations, widened pulse pressure, hypertension, tachycardia, angina, ECG

changes, ventricular fibrillation

3. GI: nausea, vomiting

4. Respiratory: dyspnoea

5. Skin: urticaria, pallor, diaphoresis

6. Other:haemorrhage at injection site

2. Nor-adrenaline

A. Main action:

 Is a vasoconstrictor that predominantly stimulates α1 receptors to cause peripheral

vasoconstriction and increase blood pressure.

 It also has some β1 receptor agonist activity that results in a positive inotropic effect

on the heart at higher doses.
B. Indications:

1. To increase blood pressure in acute, severe, hypotensive states

2. Noradrenaline is the vasopressor of choice for managing septic shock.

3. Septicemia, CHF, MI, Heart surgery, trauma

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