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Level two – Semester 4 - PharmD Biochemistry-II PB-403 (Practical course) 2024/2025
7. Indican
❖ It is a potassium salt of indoxyl sulfate.
❖ It is a product of the metabolism of tryptophan
Def. &
Source
amino acid.
Causes of 1- Severe constipation.
indican 2- Gastric cancer.
appearance 3- Gastric obstruction.
in urine
In the previous cases, indole & skatole accumulate in the small intestine.
Indole appears in blood and is oxidized into indoxyl → Conjugate with
sulfate in the liver → indoxyl sulfate → K → Indican which is excreted
+
in the urine.
Test Jaff's test → blue color in the organic layer
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