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CAPÍTULO 23  HEPATITIS CRÓNICA      253


                    riesgo concomitante de transformación              Precauciones
                    maligna.                                           Las mismas precauciones que se
                                                                       mencionaron para el interferón pegilado.
                    Dosis
                    15 μg de interferón alfacon-1 dos veces a la
                    semana por vía subcutánea.          B B  2 2



             BIBLIOGRAFÍA                                       22.  Di Bisceglie AM, Hoofnagle JH: Optimal therapy of hepatitis C.
                                                                    Hepatology 36(Suppl 1):S121-S127, 2002.
             1.  Centers for Disease Control and Prevention: Recommendations for  23.  Napoli N, Giannelli G, Parisi CV, et al: Predictive value of early
                prevention and control of hepatitis C virus (HCV) infection and  virological response to treatment with different interferon-based
                HCV-related chronic disease. MMWR 47(No. RR-19):1-33, 1998.  regimens plus ribavirin in patients with chronic hepatitis C. N
             2.  Centers for Disease Control and Prevention: National Hepatitis C  Microbiol 28:13-21, 2005.
                Prevention Strategy: A Comprehensive Strategy for the Prevention  24.  Manns M, McHutchison J, Gordon S, et al: Peginterferon alfa-2b
                and Control of Hepatitis C Virus Infection and Its Consequences.  plus ribavirin compared with interferon alfa-2b plus ribavirin for
                Atlanta, Division of Viral Hepatitis, National Center for Infectious  initial treatment of chronic hepatitis C: A randomized trial. Lancet
                Diseases, Centers for Disease Control and Prevention, Summer 2001.  358:958-965, 2001.
             3.  Saleem N, Mubarik A, Qureshi AH, et al: Is there a correlation  25.  Hadziyannis SJ, Sette H Jr, Morgan TR, et al: Peginterferon-alpha2a
                between degree of viremia and liver histology in chronic hepatitis C?  and ribavirin combination therapy in chronic hepatitis C:
                J Pak Med Assoc 54:476-479, 2004.                   A randomized study of treatment duration and ribavirin dose.
             4.  Rodriguez-Inigo E, Bartolome J, deLucas S, et al: Histological  Ann Intern Med 140:346-355, 2004.
                damage in chronic hepatitis C is not related to the extent of  26.  Veldt BJ, Saracco G, Boyer N, et al: Long-term clinical outcome
                infection in the liver. Am J Pathol 154:1877-1881, 1999.  of chronic hepatitis C patients with sustained virological response
             5.  El-Serag HB: Hepatocellular carcinoma and hepatitis C in the   to interferon monotherapy. Gut 53:1504-1508, 2004.
                United States. Hepatology 36(5 Suppl 1):S74-S83, 2002.  27.  Droge W, Pottmeyer-Gerber C, Schmidt H: Glutathione augments
             6.  Poynard T, Bedossa P, Opolon P, et al: Natural history of liver  the activation of cytotoxic T lymphocytes in vivo. Immunobiology
                fibrosis progression in patients with chronic hepatitis C. Lancet  172:151-156, 1986.
                349:825-832, 1997.                              28.  Loguercio C, Blanco FD, De Girolamo V: Ethanol consumption,
             7.  Alberti A, Benvegnu L, Boccato S, et al: Natural history of initially  amino acid, and glutathione blood levels in patients with and
                mild chronic hepatitis C. Dig Liver Dis 36:646-654, 2004.  without chronic liver disease. Alcohol Clin Exp Res 23:1780-1784,
             8.  Kleiner DE: The liver biopsy in chronic hepatitis C: A view from the  1999.
                other side of the microscope. Semin Liver Dis 25:52-64, 2005.  29.  Barbaro G, Di Lorenzo G, Soldini M: Hepatic glutathione deficiency
             9.  National Institutes of Health. Management of Hepatitis C: 2002  in chronic hepatitis C: Quantitative evaluation in patients who are
                National Institutes of Health Consensus Conference Statement.  HIV positive and HIV negative and correlations with plasmatic and
                Available online as of September 2005 at            lymphocytic concentrations and with the activity of the liver disease.
                http://consensus.nih.gov/2002/2002HepatitisC2002116html.htm.  Am J Gastroenterol 91:2569-2573, 1996.
             10.  Strader DB,Wright T, Thomas DL, Seeff LB: Diagnosis,  30.  Witschi A, Reddy S, Stofer B, Lauterburg BH: The systemic
                management, and treatment of hepatitis C. Hepatology   availability of oral glutathione. Eur J Clin Pharmacol 43:667-669,
                39:1147-1171, 2004.                                 1992.
             11.  Cotran RS, Kumar V, Robbins SL(eds): Inflammation and repair.   31.  Johnston CJ, Meyer CG, Srilakshmi JC: Vitamin C elevates red blood
                In Robbins Pathologic Basis of Disease, 5th ed. Philadelphia,   cell glutathione in healthy adults. Am J Clin Nutr 58:103-105, 1993.
                WB Saunders, 1994, pp 51-92.                    32.  Von Herbay A, Stahl W, Niederau C, Sies H: Vitamin E improves the
             12.  Lechner F, Wong DK, Dunbar PR, et al: Analysis of successful  aminotransferase status of patients suffering from viral hepatitis C:
                immune responses in persons infected with hepatitis C virus.   A randomized, double-blind, placebo controlled study. Free Radical
                J Exp Med 191:1499-1512, 2000.                      Res 27:599-605, 1997.
             13.  Shoukry NH, Grakoui A, Houghton M, et al: Memory CD8 +  33.  Look MP, Gerard A, Rao GS, et al: Interferon/antioxidant
                T cells are required for protection from persistent hepatitis C virus  combination therapy for chronic hepatitis C: A controlled pilot
                infection. J Exp Med 197:1645-1655, 2003.           trial. Antiviral Res 43:113-122, 1999.
           © Elsevier. Es una publicación MASSON. Fotocopiar sin autorización es un delito.
             14.  Thimme R, Oldach D, Chang KM, et al: Determinants of viral  34.  Chojkier M, Houglum K, Lee KS, Buck M: Long- and short-term
                clearance and persistence during acute hepatitis C virus infection.   D-α-tocopherol supplementation inhibits liver collagen a1(I) gene
                J Exp Med 194:1395-1406, 2001.                      expression. Am J Physiol 275:G1480-G1485, 1998.
             15.  Cramp ME, Rossol S, Chokshi S, et al: Hepatitis C virus-specific   35.  Houglum K, Venkataramani A, Lyche K, Chojkier M: A pilot study
                T-cell reactivity during interferon and ribavirin treatment in   of the effects of D-alpha-tocopherol on hepatic stellate cell activation
                chronic hepatitis C. Gastroenterology 118:346-355, 2000.  in chronic hepatitis C. Gastroenterology 113:1069-1073, 1977.
             16.  Kamal SM, Fehr J, Roesler B, et al: Peginterferon alone or   36.  Jain A, Buist NR, Kennaaway NG, et al: Effect of ascorbate or
                with ribavirin enhances HCV-specific CD4 T-helper 1 responses   N-acetylcysteine treatment in a patient with hereditary
                in patients with chronic hepatitis C. Gastroenterology   glutathione synthetase deficiency. J Pediatr 124:229-233, 1994.
                123:1070-1083, 2002.                            37.  Kleinveld HA, Demacker PNM, Stalenhoef AFH: Failure of
             17.  Reiser M, Marousis CG, Nelson DR, et al: Serum interleukin 4   N-acetylcysteine to reduce low-density lipoprotein oxidizability
                and interleukin 10 levels in patients with chronic hepatitis C virus  in healthy subjects. Eur J Clin Pharmacol 43:639-642, 1992.
                infection. J Hepatol 26:471-478, 1997.          38.  Beloqui O, Prieto J, Suarez M, et al: N-acetylcysteine enhances the
             18.  He XS, Rehermann B, Lopez-Labrador FX, et al: Quantitative  response to interferon-alpha in chronic hepatitis C: A pilot study.
                analysis of hepatitis C virus-specific CD8 +  T cells in peripheral   J Interferon Res 13:279-282, 1993.
                blood and liver using peptide-MHC tetramers. Proc Natl Acad Sci   39.  Ideo G, Bellobuono A, Tempini S, et al: Antioxidant drugs
                U S A 96:5692-5697, 1999.                           combined with alpha-interferon in chronic hepatitis C not
             19.  Mayo MJ: Extrahepatic manifestations of hepatitis C infection.   responsive to alpha-interferon alone: A randomized, multicentre
                Am J Med Sci 325:135-148, 2002.                     study. Eur J Gastroenterol Hepatol 11:1203-1207, 1999.
             20.  Pizzourno JE, Murray MT (eds): Detoxification. In Textbook of  40.  Look MP, Gerard A, Rao GS, et al: Interferon/antioxidant
                Natural Medicine, 2nd ed. Edinburgh, Churchill-Livingstone, 1999.  combination therapy for chronic hepatitis C: A controlled pilot trial.
             21.  Fried MW, Shiffman ML, Reddy KR, et al: Peginterferon alfa-2a plus  Antiviral Res 43:113-122, 1999.
                ribavirin for chronic hepatitis C virus infection. N Engl J Med  41.  Bernhard MC, Junker E, Hettinger A, et al: Time course of total
                347:975-982, 2002.                                  cysteine, glutathione, and homocysteine in plasma of patients with
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