Page 25 - BIO REX PAPAYA English

Anti-Inflammatory

Inflammatory conditions activate immune defense

mechanisms and, under persistent stimuli, chronic

inflammation may occur. Chronic inflammation thus triggers

the generation and progression of pro-inflammatory cytokines,

transcription factors and oncogenes.

A number of the phytochemicals found in papaya have been

shown to reduce chronic inflammatory conditions and

associated side-effects by modifying the levels of

inflammatory markers. The effect of fermented papaya on the

ethanol-related gastric mucosal inflammation and

cyanocobalamin absorption abnormality in alcoholics has

been assessed (Marotta et al., 1999).

For the gastric mucosa damage double blind study, twenty-

two healthy volunteers underwent gastroscopy during which

biopsy samples were taken for chemiluminescence assay,

routine histology, and for malonyldialdehyde (MDA). Xanthine

oxidase and glutathione determination with subjects were

given either 9g of fermented papaya preparation at bedtime

and 3h prior to blood examination, or placebo. Subjects on

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