Page 23 - BIO REX PAPAYA English
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Immunomodulator
Regulation of immune responses in a body demands balance
between T helper (TH)-1 and TH2-cell cytokines. Papaya
extract at concentrations of 0.0125–0.05 mg/ml upregulated
the production of TH1-type cytokines (IL-12p40, IL-12p70,
IFNg and TNFa) and induced 23 immunomodulatory genes in
immunosuppresed (antiCD3 and anti CD-28 monoclonal
antibody-treated) PBMC whereas reducing the amount of IL-2
and IL-4 (Otsuki et al. 2010).
Macrophage inducible nitric oxide synthase can generate
nitric oxide (NO) which contributes the host immune defense
against viruses and bacteria. A study to assess the effect of
fermented papaya on nitric oxide synthesis and TNFγ secretion
in RAW 267.7 macrophages indicated that it exerted both
immunomodulatory and antioxidant activities (Rimbach et al.,
2000).
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