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Clinical pharmacy PharmD program Third level Phytochemistry-1 (PG-504)

Pharmacological effects of flavonoids:

➢ Decrease of capillary fragility so reduce capillary bleeding, e.g. rutin,
hesperidin.

➢ Isoflavone derivatives have a distinct estrogenic effect

➢ Hepatoprotective

➢ Anti-oxidant

1. Flavone Glycosides Ex.: Diosmin

Occurs in buchu leaves

The diuretic and diaphoretic action of the leaves is owed to diosmin, and diosphenol, the
main constituent of the volatile oil of the leaf.

Uses:

• Treating various disorders of blood vessels including hemorrhoids, varicose
veins, poor circulation in the legs (venous stasis), and bleeding (hemorrhage)
in the eye or gums.

• For swelling arms (lymphedema) following breast cancer surgery.

• Protect against liver toxicity.

• It is often taken in combination with hesperidin, another plant chemical.

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