Page 125 - DUOKOPT BIBLIOBOOK

CY
EFFICA
EFFICACY

KEY MESSAGES

X A 12-month prospective study comparing Latanoprost/Timolol & Dorzolamide/Timolol
fixed combinations

X DTFC provides greater optic nerve perfusion pressure than LTFC.
X DTFC has a similar efficacy in IOP lowering than LTFC.

STRENGTHS

X DTFC provides statically significant higher perfusion pressure.

X One year of treatment with LTFC or DTFC resulted in similar IOP lowering effects as
well as stable visual function and structure after 1 year. The DTFC group showed lower
vascular resistance in retrobulbar vessels compared to the LTFC group.

WEAKNESSES

X A follow up of one year is small, too short time period to see a difference in outcome that
is unrelated to the IOP-lowering effect.

X Low number of patients (30).

MARKETING CLAIM

X 1-Year treatment of Dorzolamide-Timolol combination provides IOP reduction, a stable
visual function and a higher optic nerve perfusion.

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