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There is evidence that transport toward the nucleus takes place on
the microtubule network. 115 Most retroviruses can productively infect
only if there is breakdown of the nuclear membranes, but the PIC of
HIV can enter an intact nucleus, such as that of a resting T cell or a
macrophage and is transported through the NPC (Nuclear Pore
Complex).

Figure 7.

Viral integrase and cell enzymes are involved in the integration of
the provirus into a cell chromosome; cell enzymes remove the DNA
flap and repair the gap. There is evidence that integration of the provirus
in a resting memory CD4 T cell may result in a latent infection. Latently
infected cells can provide a reservoir of infection that is significant for
the survival of the virus in individuals receiving anti-retroviral drug
therapy. 116

115 Didelot X, Bowden R, Wilson DJ, Peto TEA, Crook DW. (2012). Transforming
clinical microbiology with bacterial genome sequencing. Nat Rev Genet.;13(9):601-
612. Url. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5049685/
116 Zennou Véronique, Petit Caroline, Guetard Denise, Nerhbass Ulf, Montagnier,
Luc, Charneau Pierre, HIV-1 Genome Nuclear Import Is Mediated by a Central DNA
Flap, op. cit.

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