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DNA strand which is the DNA synthesized by a single-stranded model
of RNA.
4. Viral DNA is transported through the nucleus, where the HIV
integrase protein integrates HIV viral DNA into the host’s DNA. Then
the normal host transcription mechanism transcribes HIV viral DNA
into multiple copies of the new HIV RNA.
5. Part of this RNA becomes the genome of a new virus, while the
cell uses other copies of the RNA to produce new HIV proteins.
6. The new viral RNA and HIV proteins move to the surface of the
cell, where a new immature HIV is formed. The capsid surrounds the
genome of the new viral RNA
7. Finally, the virus is released from the cell, and the HIV protein
called protease breaks down the newly synthesized polyproteins to
create a mature infectious virus.
At this point, the new viruses escape from the host cell. In addition,
covalent bonds are formed (a chemical bond involving the sharing of
electron pairs between atoms) between viral and host DNA that produce
a permanent alteration. This alteration is defined by the scientific
literature as ‘a point of no return’ for the host cell. In fact, this forms a
provirus that is a permanent transporter of the virus.
Among retroviruses, lentiviruses possess the unique ability to
replicate effectively in nondividing cells (and can enter cells
undergoing cellular mitosis). This mechanism at work in HIV-1 is the
PIC (pre-integration complex).
PIC is a nucleoprotein complex (of viral genetic material and
associated viral and host proteins), that is capable of inserting a viral
genome into a host genome. The PIC is formed after the Reverse
Transcription Complex has reverse transcribed/copied the viral RNA
(e.g. SARS-CoV-2 lentivirus mRNA) into the DNA referred to as
complementary DNA (cDNA). The PIC manages to cross the double
nuclear membrane of the host cells and enters the nucleus of the cell
through the NPC (Nuclear Pore Complex). 109

109 Naffakh Nadia, Molecular mechanism of transcription by influenza virus
polymerase. Url. https://research.pasteur.fr/en/project/nuclear-import-and-assembly-
of-the-viral-rna-polymerase-subunits/

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