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remain intact and constitute, for this reason, a chimeric genome of HIV-
1. 114
Image 5 and 6. How the central DNA flap works.
Thus, while the proviruses of the majority of retroviruses are entirely
DNA double-stranded, those of HIV and other lentiviruses have a short
triple-stranded sequence known as central DNA flap. After reverse
transcription has been completed, the pre-integration complex (PIC)
which contains host proteins as well as virus proteins, is transported
into the nucleus.
114 Zennou Véronique, Petit Caroline, Guetard Denise, Nerhbass Ulf, Montagnier
Luc, Charneau Pierre (April 14, 2000). HIV-1 Genome Nuclear Import Is Mediated
by a Central DNA Flap. The final product. Volume 101, ISSUE 2, pp. 173-185. Url.
https://www.cell.com/cell/fulltext/S0092-8674(00)80828-4/ - Human Immunodeficie
ncy Viruses, 18.1 Introduction to HIV. Url. https://basicmedicalkey.com/human-imm
unodeficieency-viruses/
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