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remain intact and constitute, for this reason, a chimeric genome of HIV-
                           1. 114
































                                         Image 5 and 6. How the central DNA flap works.

                             Thus, while the proviruses of the majority of retroviruses are entirely
                           DNA double-stranded, those of HIV and other lentiviruses have a short
                           triple-stranded  sequence  known  as  central  DNA  flap.  After  reverse
                           transcription has  been completed, the pre-integration complex (PIC)
                           which contains host proteins as well as virus proteins, is transported
                           into the nucleus.


                             114  Zennou Véronique, Petit Caroline, Guetard Denise, Nerhbass Ulf, Montagnier
                           Luc, Charneau Pierre (April 14, 2000). HIV-1 Genome Nuclear Import Is Mediated
                           by a Central DNA Flap. The final product. Volume 101, ISSUE 2, pp. 173-185. Url.
                           https://www.cell.com/cell/fulltext/S0092-8674(00)80828-4/ - Human Immunodeficie
                           ncy Viruses, 18.1 Introduction to HIV. Url. https://basicmedicalkey.com/human-imm
                           unodeficieency-viruses/



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