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integrase — that catalyze the steps of retroviral infection
When the retrovirus enters the healthy host cell (a protease-mediated
process), it takes over the host genetic transcription machinery to
construct a proviral DNA. This process of converting retroviral RNA
into proviral DNA is catalyzed precisely by reverse transcriptase which
is crucial for the insertion of proviral DNA into the nucleus of host
DNA, a phase initiated by the enzyme integrase. 105
In summary, reverse transcriptase is an enzyme encoded by the
genetic material of retroviruses, capable of catalyzing the
transcription/copying of retroviral RNA into proviral DNA to generate
a complementary DNA (cDNA) which is the DNA synthesized by a
single-stranded model of RNA.
Reverse transcriptase is then used by HIV-1 to replicate its genome
via the general retrotransponsion process. Its mobile genetic elements
proliferate within the host genome because retrotransponsions are a
type of genetic components that copy/paste in different genomic
locations (transponsion), through the conversion of RNA into
complementary DNA.
In the same way, trough reverse transcription, a mRNA-based
vaccine for SARS CoV-2 transcribes two strands of DNA, referred to
as complementary DNA (cDNA). Then, in translating a protein, the
mRNA molecules leave the cell nucleus and enter the cytoplasm to
synthesize individual proteins. The presence of 16 genomic fragments
of HIV-1 provides the ‘gain of function’ to the viral genome of SARS-
CoV-2 as illustrated within a slideshow. 106 The actions of SARS-CoV-
2 are now the same as for HIV itself.

The HIV replication process. Infographic 2 illustrates the HIV
replication cycle. 107 It is the model for the early events of retroviral life

105 Liguo Zhang et al. (2020). SARS-CoV-2 RNA reverse-transcribed and integrated
into the human genome. bioRxiv 2020.12.12.422516; Daniel E. Koshland, Protein. Url.
https://www.britannica.com/science/Protein/
106 Perkins Silvester, Replication of HJV. Url. https://slideplayer.com/slide/12230
998/
107 Infographic. Url. https://www.flickr.com/photos/niaid/5057022555/in/album
-72157625994990013/

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