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Complementary Non-Pharmacological Therapy to Reduce Nausea





                                                                                                                                                                                                            and Vomiting in Breast Cancer Therapy Undergoing Chemotherapy









                                                                                                                                                                                                        Dian Th Sopacua, Laili Rahayuwati, Citra Windani Mambang Sari, Raden Nabilah Putri Fauziyyah



                                                                                                                                                                                                                                                                                                         Faculty of Nursing, Universitas Padjadjaran



                                                                                                                                                                                                                                                                                                                            raden16006@mail.unpad.ac.id











             INTRODUCTION                                                                                                                                                                                                                              However, another result explained by Genç et al (2013) when doing                                                                                                                                                                  Reference




                                                                                                                                                                                                                                                       intervention of acupressure technique on his research in Turkey. The



              Chemotherapy                                       is           one                of           the              breast                    cancer                      treatments.                                                       technique on the Nei Guan spots was done alone by the patient after                                                                                                                                                                1.            Ganz PA, Kwan L, Stanton AL, Bower JE, Belin TR. Physical and psychosocial



              Chemotherapy-Induced Nausea and Vomiting (CINV) has various                                                                                                                                                                              being taught by the researcher, and they were given the nausea                                                                                                                                                                     recovery in the year after primary treatment of breast cancer. J Clin Oncol.



              severity and intensity in many cancer patients. Research has shown                                                                                                                                                                       bracelet which was flagged white. This was to place the right spots for 5                                                                                                                                                          2015;29(9):1101–1109.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Liao G-S, Apaya MK, Shyur L-F. Herbal medicine and acupuncture for breast
              that pharmacological therapy is less effective in decreasing the                                                                                                                                                                         days to overcome the nausea and vomiting problems during                                                                                                                                                                           cancer palliative care and adjuvant therapy. Evidence-Based Complement Altern Med.



              incidence of nausea and vomiting during chemotherapy, therefore,                                                                                                                                                                         chemotherapy. As a result, it showed that there was no significant                                                                                                                                                                 2013;



              some patients choose nonpharmacological methods. This systematic                                                                                                                                                                         difference between control group and intervention group regarding the                                                                                                                                                              3.            Chan A, Low XH, Yap KY-L. Assessment of the relationship between adherence



              review aims to identify non-pharmacological treatments to help breast                                                                                                                                                                    reduced intensity of nausea and vomiting after the intervention.                                                                                                                                                                   with antiemetic drug therapy and control of nausea and vomiting in breast cancer
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          patients receiving anthracycline-based chemotherapy. J Manag Care Pharm [Internet].

              cancer                     patients                       in          reducing                        nausea                       and                vomiting                       during                                                                                                                                                                                                                                                                                 2012;18(5):385–94.                                                                                      Available                                                                        from:


              chemotherapy.                                                                                                                                                                                                                            In this review, there are some non pharmacological interventions                                                                                                                                                                   http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L36541



                                                                                                                                                                                                                                                       considered proven and successful to reduce nausea and vomiting.                                                                                                                                                                    2993%5Cnhttp://www.amcp.org/WorkArea/DownloadAsset.aspx?id=15284

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          4.
             METHODS                                                                                                                                                                                                                                   Moradian’s research explained the effect of nevasic audio intervention                                                                                                                                                             induced nausea and vomiting in asian women with breast cancer receiving
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Bourdeanu L, Frankel P, Yu W, Hendrix G, Pal S, Badr L, et al. Chemotherapy-



                                                                                                                                                                                                                                                       to reduce nausea and vomiting. This intervention was done by listening                                                                                                                                                             anthracycline-based adjuvant chemotherapy. J Support Oncol. 2012;10(4):149–154.



             The systematic research is conducted by examining three electronic                                                                                                                                                                        to nevasic (An audio-medical program that stabilizes the inner part of                                                                                                                                                             5.            Taspinar A, Sirin A. Effect of acupressure on chemotherapy-induced nausea and

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          vomiting in gynecologic cancer patients in Turkey. 2010;14(1):49–54.

             databases, named Pubmed, CINAHL Ebsco, and Proquest. The                                                                                                                                                                                  the ear by giving help while nauseated or vomiting). The two groups                                                                                                                                                                6.            Limon-miro AT, Lopez-teros V, Astiazaran-garcia H. Dietary Guidelines for Breast



             study was conducted in the period between 2007 and 2019 and the                                                                                                                                                                           were also given a semi-permanent interview to identify the participant’s                                                                                                                                                           Cancer Patients : A Critical Review. Adv Nutr an Int Rev J. 2017;613–623.

                                                                                                                                                                                                                                                       perspective about the burden of finishing the intervention. The result of
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          7.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Najafi S, Haghighat S, Lahiji MR, RazmPoosh E, Chamari M, Abdollahi R, et al.
             research design provided in the review was only a Randomized                                                                                                                                                                              this research did not show nevasic effectiveness to reduce nausea and                                                                                                                                                              Randomized study of the effect of dietary counseling during adjuvant chemotherapy on



             Controlled Trial (RCT).                                                                                                                                                                                                                   vomiting, but it significantly reduced the participant’s willingness to use                                                                                                                                                        chemotherapy induced nausea and vomiting, and quality of life in patients with breast

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          cancer. Nutr Cancer. 2019;71(4):575–584.

                                                                                                                                                                                                                                                       antimetics (anti-vomiting) (p=0.003). The other intervention that could                                                                                                                                                            8.            Suh EE. The effects of P6 acupressure and nurse-provided counseling on



              RESULT                                                                                                                                                                                                                                   reduce nausea and vomiting for breast cancer patients was Bali Yoga in                                                                                                                                                             chemotherapy-induced nausea and vomiting in patients with breast cancer. Oncol Nurs


                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Forum. 2012;39(1):E1–E9.
                                                                                                                                                                                                                                                       8 sessions for 90 minutes. However, the result of the research is Bali



                                                                                                                                                                                                                                                       Yoga therapy was not proven to give a significant result between                                                                                                                                                                   9.            Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JPA, et al.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          The PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses of
              The total articles obtained were 467, and only 10 articles met the                                                                                                                                                                       intervention group and control group (17,18).                                                                                                                                                                                      Studies That Evaluate Health Care Interventions: Explanation and Elaboration. J Clin


              inclusion criteria and were then analyzed which the total sample is                                                                                                                                                                                                                                                                                                                                                                                                         Epidemiol. 2009;62.



              948. The interventions found in this review are acupressure, ginger,                                                                                                                                                                                                                                                                                                                                                                                                        10.           Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for



              listening to the nevasic program and counselling dietary. Most of                                                                                                                                                                        CONCLUSION                                                                                                                                                                                                                         systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;



              the instruments used are the Numeric Rating Scale (NRS) and                                                                                                                                                                                                                                                                                                                                                                                                                 11.           Dibble S, Luce J, Cooper B, Israel J, Cohen M, Nussey B, et al. Acupressure for
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          chemotherapy-induced nausea and vomiting: a randomized clinical trial. Oncology

              Index of Nausea, Vomiting and Retching (INVR).                                                                                                                                                                                      In this systematic review, it is identified that there are some interventions                                                                                                                                                           Nursing Forum. Oncol Nurs Forum. 2007;34(4):1–8.
                                                                                                                                                                                                                                                  proven to reduce and overcome nausea and vomiting including                                                                                                                                                                             12.           Eghbali M, Yekaninejad MS, Varaei S, Jalalinia SF, Samimi MA, Sa’atchi K. The



                                                                                                                                                                                                                                                  acupressure technique on Nei Guan spots and auricular spots,                                                                                                                                                                            effect of auricular acupressure on nausea and vomiting caused by chemotherapy among



            DISCUSSION                                                                                                                                                                                                                            consumption of ginger and consultation with nutritionist and diet                                                                                                                                                                       breast cancer patients. Complement Ther Clin Pract. 2016;24:189–194.

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          13.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        Genç A, Can G, Aydiner A. The efficiency of the acupressure in prevention of the
                                                                                                                                                                                                                                                  specialists. These interventions could be done independently by the



              Upon reviewing 10 articles, it was obtained that the most common                                                                                                                                                                    nurses including clinical, community, or pedagogic nurses, and there was                                                                                                                                                                chemotherapy-induced nausea and vomiting. Support Care Cancer. 2013;21(1):253–
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          261.


              intervention was acupressure therapy to reduce nausea and                                                                                                                                                                           no risk emerging. The researcher suggests that the upcoming research                                                                                                                                                                    14.           Giacosa A, Morazzoni P, Bombardelli E, Riva A, Porro GB, Rondanelli M. Can



              vomiting when undergoing acupressure therapy to reduce nausea                                                                                                                                                                       add more samples to be generalized to be utilised as a valid data.                                                                                                                                                                      nausea and vomiting be treated with ginger extract? Science. Eur Rev Med Pharmacol
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Sci. 2015;19(7):1291–6.

              and vomiting while undergoing chemotherapy treatment for breast                                                                                                                                                                     Therefore, non pharmacological therapy could be applied as Evidence                                                                                                                                                                     15.           Arslan M, Ozdemir L. Oral intake of ginger for chemotherapy-induced nausea and



              cancer patients (8,11). Another research discussing the effect of                                                                                                                                                                   Based Practice (EBP) to improve healthcare services.                                                                                                                                                                                    vomiting among women with breast cancer. Clin J Oncol Nurs. 2015;19(5):E92–E97.


              acupressure (12) but the acupressure spots were different from                                                                                                                                                                                                                                                                                                                                                                                                              16.           Salihah N, Mazlan N, Lua PL. The effectiveness of inhaled ginger essential oil in

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          improving dietary intake in breast-cancer patients experiencing chemotherapy-induced
              other research such as auricular or the patient’s earlobes. The                                                                                                                                                                                                                                                                                                                                                                                                             nausea and vomiting. Focus Altern Complement Ther. 2016;21(1):8–16.



              result showed that by doing acupressure technique on the auricular                                                                                                                                                                                                                                                                                                                                                                                                          17.           Moradian S, Walshe C, Shahidsales S, Ghavam Nasiri MR, Pilling M, Molassiotis



              spots proved effective to reduce intensity on nausea and vomiting                                                                                                                                                                                                                                                                                                                                                                                                           A. Nevasic audio program for the prevention of chemotherapy induced nausea and



              level for acute and suspended phases on the experimental group                                                                                                                                                                                                                                                                                                                                                                                                              vomiting: A feasibility study using a randomized controlled trial design. Eur J Oncol Nurs.
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          2015;19(3):282–291.
              (p=0.001).                                                                                                                                                                                                                                                                                                                                                                                                                                                                  18.           Anestin AS, Dupuis G, Lanctôt D, Bali M. The effects of the bali yoga program for



                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          breast cancer patients on chemotherapy-induced nausea and vomiting: results of a


                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          partially randomized and blinded controlled trial. J Evidence-Based Complement Altern


                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          Med. 2017;22(4):721–730.



























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                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             4 Udayana International Nursing Conference
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