Page 1024 - The Toxicology of Fishes

1004 The Toxicology of Fishes

polyunsaturated fatty, 194, 292, 304 adriamycin, 85
resin, 352, 937, 944, 949, 954, 957 adsorbable organic halogen (AOX), 954, 957
retinoic, 285, 419 advection, 67, 647
sulfuric, 38 AFB , see aflatoxin B 1
1
tannic, 300 AFB -8,9-epoxide (AFBO), 167, 210, 540
1
taurocholic, 362 –DNA adducts, 210, 211–212, 213
threonic, 283 –GSH adducts, 212
unsaturated fatty, 208, 295, 372 affinity, 240–244, 247
uric, 285 aflatoxicol (AFL), 212, 562
ursodeoxycholic, 365 aflatoxicol B , 369
1
valproic, 252 aflatoxicol M (AFLM ), 212, 562
1
1
weak organic, 61, 79 aflatoxin, 164, 178, 188, 207, 209–213, 533, 537,
Acipenser fulvescens, 696, 847; see also lake 538–540, 562, 563, 564, 572
sturgeon hepatocarcinogenicity of, 371
Acipenser transmontanus, 342; see also sturgeon -induced hepatic nodules, 607
aconitase, 286 metabolites, 572
acrolein, 191 aflatoxin B (AFB ), 167, 209–213, 369, 538,
1
1
acrosome reaction, 462, 465 539–540, 542–543, 551, 552, 557, 560, 562,
acrylamide, 163, 427 563, 564, 565, 566, 567, 569, 570, 571, 572,
actinopterygians, 421 698
activated carbon–water partition coefficients, 43 –deoxyguanine adducts, 543
activation, receptor, 244 –DNA adducts, 543, 552, 569
active transport, 63, 83 inhibitors of, 567
activin, 460, 461 –DNA binding, 211
actual exposure, 927, 928 glucuronide, 369
acute-phase proteins, 490, 494 metabolites, 540
acute-to-chronic toxicity ratio (ACR), 677, 678 aflatoxin B -8,9-epoxide, see AFB -8,9-epoxide
1
1
acute toxicity, 5, 660, 787, 788, 801, 807, 944, (AFBO)
949–950, 953 aflatoxin M (AFM ), 211, 212, 540, 562
1
1
acute toxicity tests, 660, 662, 675–676, 808, aflatoxin Q , 570
1
949–950, 954 AFLM , 212, 562
1
acyl-CoA (CoA), 206, 357 AFP , 211
1
acyl-CoA oxidase (AOX), 357, 358 AFQ , 211
1
adaptation, 600, 607, 609, 621, 624, 625, 627 African catfish (Clarias gariepinus), 91
genetic, 598–599, 601, 608, 609, 610, 611, gonadotropin receptors in, 459
613, 616, 618, 622, 624, 626, 627 aging, oxidative stress and, 295
signaling, 828 aglycones, 184, 185
adenohypophysis, 458 agnathans, 489
adenoma, 533 agonists, 245, 252, 470
adenosine triphosphatase, see ATPase AhR, see aryl hydrocarbon receptor
adenosine triphosphate (ATP), 63, 85, 88, 89, 184, AhR interacting protein (AIP), 828
191, 199, 275, 295, 362, 363, 407, 435, 606 AhR nuclear translocator (ARNT), 160, 253, 256
adenylate cyclase, 463 AhR repressor (AhRR) gene, 253
adenylyl cyclase, 459, 466, 469 AhR response elements (AhREs), 160, 253, 828,
adipose tissue, 43, 78, 80, 110, 194 832, 833, 834
Adirondack lakes, 38 binding, 834–835
adrenal cortex, 459 AhR1, 251, 253, 256, 604, 615, 616, 624
adrenal gland, 85, 564 AhR1A, 250
adrenaline, 405–406, 423, 702 AhR2, 250, 251, 253, 256, 604, 615, 616, 833
adrenocortical functions, 458 AhR3, 256
adrenocorticotropic hormone (ACTH), 410, AhRR, 615, 616, 827
474–475, 476 alachlor, 190
adrenocorticotropin, 459 alanine aminotransferase, 406