Page 1029 - The Toxicology of Fishes

Index 1009

canaliculi, 84, 85, 337, 338, 339, 343, 359, biliverdin reductase, 691
692 binding capacity (R ), 240, 241, 242, 244, 245,
T
ducts, 84, 338, 347, 359 247
ductular epithelial cells, 338 binding constants, 241
ductules, 337, 338, 359 bioaccumulation, 19, 41, 42, 44, 126, 128–134,
flow, 359, 360, 363–364 503, 506, 507, 601, 602, 654–656, 736, 744,
flow rates, 86, 120 791, 794, 798, 807, 882–885
fluorescent aromatic compounds, 352, 884, benzo(a)pyrene, 42
885, 886, 889, 890, 891, 892, 893, 894, defined, 56, 126
895, 903, 911 food web models of, 131–134
formation of, 330 hepatic metabolism, and, 369
in medaka, 343 model, for pulp mill effluents, 956
glucuronides in, 186 polycyclic aromatic hydrocarbons, 42
homeostasis, 360, 361, 364 TCDD, 39
loss, 434 tests, 678–679
PAH concentrations in, 910 bioaccumulation factor (BAF), 19, 20, 44,
PAH metabolites in, 885–886, 889, 890, 897, 128–131, 883, 884
911 bioactivation, 154, 208
phase II conjugates in, 352 carbon tetrachloride, 371
polycyclic aromatic compound metabolites bioassays, 573–574, 646, 684, 909, 955, 957,
in, 910 993
preductular epithelial cells, 359 7-day, 950
preductules, 338 pickle-jar, 660
rainbow trout, 812 static exposure, 809
salt, 355, 360, 362, 363, 364 synthetic pyrethroid, 807
export pump, 361, 362 bioavailability, 5, 128, 130, 131, 440, 603, 646,
transporters, 361 654, 882, 884, 957
sulfonate conjugates in, 201 ammonia, 20–24
synthesis, 359–364 ammonium ion, 23
thyroid glucuronides in, 189 assessing, 11–44
transport, 359–364 case studies, 20–44
bile acid, 154, 169, 184, 185, 191, 200, 206, 353, measures used, 19–20
354, 355, 356, 360, 365, 424 benzo(a)pyrene, 42–44
accumulation, 358 chemical, 9–45
nuclear receptors, and, 358 copper, 28–35
sulfate ester as, 201 [ C]-PCB 77, 18
14
bile/plasma concentration ratios, 85 defined, 10
bile preductular epithelial cells (BPDECs), 335, dietary, 71
338, 339, 340 mercury, 35–39
bile salt export pump (BSEP), 361, 362 methylmercury, 75
biliary elimination, 83–86, 117, 120, 123, 330, oral, 17, 71, 73, 75, 94, 102, 114, 126
352, 359, 566 oxolinic acid, 73, 75
biliary epithelial cells, 332, 337–339, 350, 359, phenols, 24–28
360, 361 sulfadimethoxine, 73
biliary lumen, 338 TCDD, 39–42
biliary secretion, 83 temperature, and, 75
biliary system, intrahepatic, 337–339 biochanin A, 167
biliary system toxicity, 364–367 biochemical oxygen demand (BOD), 937, 944,
biliary tumors, 572 953
bilirubin, 183, 184, 185, 186, 188, 191, 199, 285, biocides, 440, 618
348, 359, 691, 696 bioconcentration, 19, 126, 127–128, 131, 134, 352
conjugates, 362 defined, 56, 126
biliverdin, 691, 695, 696 hydrodynamic-based model for, 67