Page 202 - Veterinary Toxicology, Basic and Clinical Principles, 3rd Edition

Toxicoproteomics in Diagnostic Toxicology Chapter | 10 169

VetBooks.ir in venom, assess geographic venom variability and evalu- to proteomics researchers. Despite these concerns, toxico-
proteomics has the potential to better define molecular
ate antivenin efficacy. In one study conducted in venom
from the Asian forest scorpion (Heterometrus petersii), 10
mechanisms of toxicity and elucidate biomarkers or signa-
families of venom peptides and proteins were identified. ture protein profiles for clinical and diagnostic toxicology.
The proteins identified in the venom were potassium This technology promises to establish new guidelines for
channel toxins, antimicrobial and cytolytic peptides, cal- preventive and predictive toxicity, ultimately revolutioniz-
cium channel toxins, La1-like peptides, phospholipase ing and redefining our future understanding of toxicology.
A2, serum proteases, acid phosphatases, and diuretic pep-
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