Page 484 - Veterinary Toxicology, Basic and Clinical Principles, 3rd Edition

Manganese Chapter | 30 451

VetBooks.ir source. Some studies investigatingMnpoisoningsuggest its effects on signal transduction pathways, as well as
studies on effective diagnosis and treatment, are needed.
that chelation therapy may be considered to reduce the body
burden of Mn and to alleviate toxicity symptoms. Chelators
bind metal ions in a stable form and the compound chelator ACKNOWLEDGMENTS
plus metal are then excreted by the urinary and/or biliary
routes. Ethylene diaminetetraacetic acid (EDTA) is a polya- The authors gratefully acknowledge support by a grant from the
minocarboxylic acid that chelates many divalent metals, Department of Defense W81XWH-05-1-0239 (DM). The authors
a property that finds commercial application as a metal would like to thank Mrs. Robin B. Doss for her technical assistance
sequestrant in food additives. Several studies suggested that in the preparation of this chapter.
EDTA successfully increased Mn excretion in urine and
decreased Mn concentration in blood. However, EDTA REFERENCES
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