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CHAPTER 69 Disorders of the Joints 1209
and a treatment trial with doxycycline has been ineffective. Foley J, et al. Association between polyarthritis and thrombocyto-
Serologic tests for circulating RF (using the canine Rose- penia and increased prevalence of vectorborne pathogens in
VetBooks.ir Waaler or ELISA test) are positive in most literature reports Greene CE, et al. Ehrlichia and Anaplasma infections. In: Greene
Californian dogs. Vet Rec. 2007;160:159.
of cats with rheumatoid-like arthritis, but a positive test is
CE, ed. Infectious diseases of the dog and cat. 4th ed. Philadelphia:
not essential for diagnosis (Hanna, 2005).
Elsevier; 2006.
Rheumatoid-like arthritis is an aggressive, destructive, Hanna FY. Disease modifying treatment for feline rheumatoid
and irreversible disease. Most cats have only a minimal arthritis. Vet Comp Orthop Traumatol. 2005;18:94.
response to treatment with NSAIDs or glucocorticoids. Jacques D, et al. A retrospective study of 40 dogs with polyarthritis.
There have, however, been reports of remarkable improve- Vet Surg. 2002;31:428.
ment in cats treated with methotrexate in combination with Littman MP, et al. ACVIM Small Animal Consensus statement on
leflunomide (Hanna, 2005) (see Table 69.3). Treatment with Lyme disease in dogs: diagnosis, treatment and prevention. J Vet
other potent immunosuppressive agents should also be con- Intern Med. 2006;20:422.
sidered. Concurrent treatment with analgesics such as aman- Johnson KC, Mackin A. Canine immune-mediated polyarthritis,
tadine (3 mg/kg PO q24h), amitriptyline (0.5-2 mg/kg PO Part 1: pathophysiology. J Am Anim Hosp Assoc. 2012;48:12.
q24h), or gabapentin (2-10 mg/kg PO q24h) may make Johnson KC, Mackin A. Canine immune-mediated polyarthritis,
affected cats more comfortable. Part 2: diagnosis and treatment. J Am Anim Hosp Assoc.
2012;48:71.
Lemetayer J, Taylor S. Inflammatory joint disease in cats: diagnostic
Suggested Readings approach and treatment. J Feline Med Surg. 2014;16:547.
Agut A, et al. Clinical and radiographic study of bone and joint Muir P, et al. Detection of DNA from a range of bacterial species
lesions in 26 dogs with leishmaniasis. Vet Rec. 2003;153:648. in the knee joints of dogs with inflammatory knee arthritis and
Berg RIM, et al. Effect of repeated arthrocentesis on cytologic associated degenerative anterior cruciate ligament rupture.
analysis of synovial fluid in dogs. J Vet Intern Med. 2009;23: Microb Pathog. 2007;42:47.
814. Olsson M, et al. A novel unstable duplication upstream of HAS2
Bleedorn JA, et al. Synovitis in dogs with stable stifle joints and predisposes to a breed-defining skin phenotype and a periodic
incipient cranial cruciate ligament rupture: a cross-sectional fever syndrome in Chinese Shar-Pei dogs. PLoS Genet.
study. Vet Surg. 2011;40:531. 2011;7:e1001332. [Epub Mar 17, 2011].
Clements DN, et al. Type I immune-mediated polyarthritis in dogs: Rhoades AC, et al. Comparison of the efficacy of prednisone and
39 cases (1997-2002). J Am Vet Med Assoc. 2004;224:1323. cyclosporine for treatment of dogs with primary immune medi-
Clements DN, et al. Retrospective study of bacterial infective endo- ated polyarthritis. J Am Vet Med Assoc. 2016;248:395.
carditis in 31 dogs. J Small Anim Pract. 2005;46:171. Rondeau MP, et al. Suppurative, nonseptic polyarthropathy in dogs.
Colopy SA, et al. Efficacy of leflunomide for treatment of immune J Vet Intern Med. 2005;19:654.
mediated polyarthritis in dogs: 14 cases (2006-2008). J Am Vet Rychel JK. Diagnosis and treatment of osteoarthritis. Top Compan-
Med Assoc. 2010;236:312. ion Anim Med. 2010;25:20.
Danielson F, et al. Inflammatory response in dogs with spontane- Vanderweerd C, et al. Systematic review of efficacy of nutraceuti-
ous cranial cruciate ligament rupture. Vet Comp Orthop Trauma- cals to alleviate clinical signs of osteoarthritis. J Vet Intern Med.
tol. 2005;17:237. 2012;26:448.
Drugs Used in Joint Disease
DRUG NAME (TRADE RECOMMENDED DOSE
NAME) PURPOSE DOG CAT
Acetylsalicylic acid (aspirin) Analgesia, antiinflammatory 10-20 mg/kg PO q8h 10 mg/kg PO q48h
Amantadine Analgesia 3-5 mg/kg PO q24h 3 mg/kg PO q24h
Amoxicillin Antibiotic 22 mg/kg PO q12h Same
Amoxicillin with clavulanic Antibiotic 12-25 mg/kg PO q8h Same
acid (Clavamox)
Ampicillin Antibiotic 22 mg/kg PO q8h or Same
22 mg/kg IV, SC, IM q6h
Azathioprine (Imuran) Immunosuppression 2.2 mg/kg PO q24-48h Not recommended
Buprenorphine (injectable) Analgesia 0.01-0.03 mg/kg IM q8h 0.01-0.03 mg/kg on
oral mucosa q8h
Carprofen (Rimadyl) Analgesia, antiinflammatory 2.2 mg/kg PO q12h None
Continued