Page 168 - Medicinal Chemistry Self Assessment

4. The mechanism of action of this class of to interact with the ATP-sensitive potassium groups.
Answer

B
A
C D
Tolbutamide

5. Tolbutamide has a half-life of 4.5 to 6.5 hourssignificantly longer half-life than tolbutamide.
2.12 Chlorpropamide and Other Sulfonylureas 157
Answer

Metabolism of Tolbutamide

Z oxidation

Z-1 oxidation
Benzylic
oxidation

1. Alcohol
dehydrogenase

2. Aldehyde
dehydrogenase

Metabolism of Chlorpropamide

Z oxidation

Z-1 oxidation

Electron withdrawing
halogen prevents
aromatic oxidation