Page 173 - Medicinal Chemistry Self Assessment
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162    Medicinal Chemistry Self Assessment

            Chapter 2.13 (removed bolded drug names)

                Answer

                                  O         O                H              NH 2
                                                       N      N                  O
                       H 3 C   O          N                                 N
                                                        N                        O(CH ) CH
                                       N                                              2 5  3
                                                          CH 3


                                                   Dabigatran Prodrug





                 O          O               H               NH 2

                                       N      N                  O
             H O         N                                  N
                                                                     2 5
                       N                N                        O(CH ) CH 3
                                          CH 3


                                                            O          O               H               NH 2
                                                                                  N      N
                                                  H 3 C   O         N                                  NH
                                                                                   N
                                                                  N
                                                                                     CH 3










                                     O          O               H               NH 2
                                                           N      N
                                 H O         N                                  NH

                                           N                N
                                                              CH 3



                                                Active form of Dabigatran
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