Page 29 - Medicinal Chemistry Self Assessment

18 Medicinal Chemistry Self Assessment

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2. Tolterodine (Detrol ), fesoterodine (Toviaz ), and oxybutynin (Ditropan ) are anticholinergic agents
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2. Tolterodine (Detrol ), fesoterodine (Toviaz ), and oxybutynin (Ditropan ) are anticholinergic agents
used in the treatment of overactive bladder. Based on the structure evaluation process described in
used in the treatment of overactive bladder. Based on the structure evaluation process described in
Chapter 6* and previous chapters,* “read” each of these drug molecules and determine how each
of these drug molecules interact via hydrogen bonding with the muscarinic receptor. Fill in the grid
provided with your answers.

Tolterodine Fesoterodine

Oxybutynin

Function
Function One amino acid that interacts (via side
H-bond donor, chain) with the functional group via a
Name of Name of ALL Anticholinergics H-bond acceptor, complementary H-bonding interaction;
Functional Group That Contain Functional Group both or neither NONE is a possible answer