Page 281 - Pharmacognosy 2 PG303
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Pharmacognosy-2 (PG303)                              Level 2                Clinical Pharmacy-Pharm D

                                  3)  with fehling solution give                                    (2)  Powder/ether,  extract
                                      red ppt.                                                      with  CHCl₃,  dry  on  filter
                                                                                                    paper,  yellow  stain,  by
                                                                                                    treatment with hot saturated
                                                                                                    boric  acid  solution,  an
                                                                                                    orange     red    color   is
                                                                                                    produced  turns  into  bluish
                                                                                                    black  color  by  addition  of
                                                                                                    ammonia.

                  Uses            ▪  treatment of cough              ▪  anti-emetic                 ▪  appetite stimulant and    ▪  Stimulant and
                                      (expectorant)                  ▪  Aromatic flavoring and         digestive.                    carminative properties .
                                                                                   .
                                  ▪  sweetening agent                   condiment                   ▪  rice colorant.            ▪  Prevent vomiting ( for
                                  ▪  demulcent                       ▪  Anti-inflammatory           ➢  Curcumin is proved to         sea sickness)
                                  ▪  anti-inflammatory                  (arthritis ,bronchitis)        have :                    ▪  Antifungal against
                                                                                                                                                      .
                                  ▪  anti-ulcer                      ▪  Circulatory stimulant, it is   ▪  antioxidant                Candida albicans
                                  ▪  antioxidant & antitumor            a                             ▪   anti-inflammatory  )
                                  ▪  antiviral                          good choice for chronic           treat arthritis)
                                  ▪  for menopausal disorder            cold hands and feet.          ▪  anticholesterolemic
                                  ➢  Side effects :                  ▪  lower cholesterol and             (prevent heart
                                      Electrolyte disturbance           prevent the blood from              diseases)
                                      (hypokalemia, hypertension)       clotting (prolongation of     ▪  anticancer
                                   due to the corticosteroid -like      bleeding time)                ▪  treat HIV .
                                   action of glycyrrhizin
                  Notes            ▪  Interaction with drugs:        ➢  Adulteration & detection?    ➢  Curcuma is prepared
                                  ✓  With diuretics cause            ✓  Precautions:                     by (steam distillation)
                                      hypokalemia and paralysis.     ✓  should not be used by       ➢  The bioavailability of
                                  ✓  Increase the adverse effect of     children under 2 years          curcumin increased
                                      corticosteroids.                  of age .                        when co-administrated
                                  ✓  Toxicity of digoxin increased  ✓  excessive doses may              with black pepper.
                                             +
                                      when K  level is low.             cause mild heartburn.
                                                                     ✓  It should not be used
                                                                        during pregnancy!!?


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