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1204.e2 Bone Neoplasia

Bone Neoplasia
VetBooks.ir Comparison of Primary Bone Tumors of the Appendicular Skeleton in Dogs

Osteosarcoma Chondrosarcoma Fibrosarcoma Hemangiosarcoma
Incidence of overall bone tumors 80%-85% 10% <5% <5%
Prevalence in appendicular 75% 11% <40% <50%
versus axial skeleton
Age Median 7-8 years 5-9 years Mean 8.4 years Young to middle-aged
Sex predilection None (historically, male) None None None
Breed predilection Large and giant breeds Medium to large breeds (golden Medium to large breeds Medium to large breeds
retrievers) (German shepherds, boxers,
Great Danes)
Radiographic findings Osteolytic and osteoproductive Osteolytic with periosteal Primarily lytic Primarily lytic with
reaction considerable intramedullary
extension
Histopathologic findings Malignant spindle cells producing Malignant spindle cells Malignant tumor of fibrous Malignant tumor of vascular
osteoid producing neoplastic chondroid connective tissue endothelium
in a fibrillar matrix
Sites Metaphyseal; forelimb > hindlimb; Primarily metaphyseal; hindlimb Metaphyseal and Proximal and distal third
distal radius primary > forelimb diaphyseal of long bones; proximal
humerus primary
Metastatic rate without treatment 90% before 1 year 20% (very slow)-100% 6% Very high, at least 88%
Metastatic sites Lung > bone Lung primary Multiple Multiple
Prognosis improved with tumor Yes Yes Yes Unknown
removal
Prognosis improved with Yes Unknown Unknown Unknown (possibly with
adjuvant chemotherapy doxorubicin)
Median survival without 3-5 months <2 months Unknown <3 months
treatment
Median survival with treatment 12 months 19 months 47% survival at 1 year <5 months; <10% 1-year
survival rate with amputation
Prognostic factors Age, tumor size, percentage of Histologic grade, location (i.e., Degree of histologic Unknown; all histologic
tumor necrosis, tumor microvessel if not resectable) differentiation grades carry a grave
density, histologic grade, serum prognosis
alkaline phosphatase
From Slatter D: Textbook of small animal surgery, ed 3, Philadelphia, 2003, Saunders.

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