Page 587 - Small Animal Internal Medicine, 6th Edition

CHAPTER 34 Diagnostic Tests for the Hepatobiliary and Pancreatic System 559

pancreatitis, but in humans there is clear evidence that early Gómez-Ochoa P, et al. Use of transsplenic injection of agitated
surgery in acute pancreatitis actually increases mortality saline and heparinized blood for the ultrasonographic diagnosis
VetBooks.ir compared with delaying surgery for 2 to 4 weeks after Goodband EL, et al. Validation of a commercial 1,2-O-Dilauryl-
of macroscopic portosystemic shunts in dogs. Vet Radiol Ultra-
sound. 2011;52:103.
symptom onset, and thus this is avoided unless there is a
high suspicion of malignant neoplasia (McKay et al., 2004;
Wittau et al., 2010). Rac-Glycero Glutaric Acid-(6′-methylresorufin) ester lipase
assay for diagnosis of canine pancreatitis accepted for publica-
However, bearing all these factors in mind, it is still well tion. Vet Record Open. 2018 26;5(1):e000270.
worthwhile taking a careful pancreatic biopsy in any animal Graca R, et al. Validation and diagnostic efficacy of a lipase assay
that is having an exploratory laparotomy or surgery for using the substrate 1,2-o-dilauryl-rac-glycero glutaric acid-(6’
another reason, and pancreatitis is a possibility. In the past, methyl resorufin)-ester for the diagnosis of acute pancreatitis in
these were discouraged because of a fear of postoperative dogs. Vet Clin Pathol. 2005;4:39.
pancreatitis. However, this appears to be a theoretical rather Hall EJ, et al. Laboratory evaluation of hepatic disease. In: Villiers
than real concern as long as the surgeon only takes a small E, Blackwood L, eds. BSAVA manual of canine and feline clinical
biopsy and preserves pancreatic blood supply. pathology. 2nd ed. Gloucestershire, England: British Small
Pancreatic biopsy appears to be safe and does not carry a Animal Veterinary Association; 2005.
high risk of postoperative pancreatitis, provided that the Hess RS, et al. Clinicopathological, radiographic and ultrasono-
graphic abnormalities in dogs with fatal acute pancreatitis: 70
pancreas is handled gently and the blood supply is not dis- cases (1986-1995). J Am Vet Med Assoc. 1998;213:665.
rupted. A study of pancreatic biopsy in 27 normal dogs Jensen AL, et al. Preliminary experience with the diagnostic value
showed elevations in some pancreatic enzyme levels postbi- of the canine corticosteroid-induced alkaline phosphatase isoen-
opsy but not in cPLI, and there were no clinical signs of zyme in hypercorticism and diabetes mellitus. Zentralbl Veteri-
pancreatitis after surgery (Cordner et al., 2010). narmed. 1992;39:342.
Kelley D, et al. Thromboelastographic evaluation of dogs with acute
Suggested Readings liver disease. J Vet Intern Med. 2015;29:1053.
Adrian AM, et al. Computed tomographic angiography under Koblik PD, et al. Transcolonic sodium pertechnetate tc 99m scin-
sedation in the diagnosis of suspected canine pancreatitis: a pilot tigraphy for diagnosis of macrovascular portosystemic shunts in
study. J Vet Intern Med. 2015;29:97. dogs, cats, and pot-bellied pigs: 176 cases (1988-1992). J Am Vet
Aravinthan A, et al. The senescent hepatocyte gene signature in Med Assoc. 1995;207:729.
chronic liver disease. Exp Gerontol. 2014;60:37. Kook PH, et al. Agreement of serum spec cPL with the 1,2-
Bahr KL, et al. Accuracy of US-guided FNA of focal liver lesions in o-dilauryl-rac-glycero glutaric acid-(6′-methylresorufin) ester
dogs: 140 cases (2005-2008). J Am Anim Hosp Assoc. 2013;49:190. (DGGR) lipase assay and with pancreatic ultrasonography in
Balkman CE, et al. Evaluation of urine sulfated and nonsulfated bile dogs with suspected pancreatitis. J Vet Intern Med. 2014;28:863.
acids as a diagnostic test for liver disease in dogs. J Am Vet Med Kortum AJ, et al. Hepatocyte expression and prognostic impor-
Assoc. 2003;222:1368. tance of senescence marker p21 in liver histopathology samples
Bigge LA, et al. Correlation between coagulation profile findings from dogs with chronic hepatitis. J Vet Intern Med. 2018;32:1629.
and bleeding complications after ultrasound-guided biopsies: Kuzi S, et al. Plasma antithrombin activity as a diagnostic and prog-
434 cases (1993-1996). J Am Anim Hosp Assoc. 2001;37:228. nostic indicator in dogs: a retrospective study of 149 dogs. J Vet
Bjorneby JM, Kari S. Cytology of the pancreas. Vet Clin North Am Intern Med. 2010;24:587.
Small Anim Pract. 2002;32:1293–1312. Lawler DF, et al. Benign familial hyperphosphatasemia in Siberian
Cole T, et al. Diagnostic comparison of needle biopsy and wedge Huskies. Am J Vet Res. 1996;57:612.
biopsy specimens of the liver in dogs and cats. J Am Vet Med Lee KC, et al. Association of portovenographic findings with
Assoc. 2002;220:1483. outcome in dogs receiving surgical treatment for single con-
Collings AJ, et al. A prospective study of basal insulin concentra- genital portosystemic shunts: 45 cases (2000-2004). J Am Vet
tions in dogs with congenital portosystemic shunts. J Small Anim Med Assoc. 2006;229:1122.
Pract. 2012;53:228. Liptak JM. Hepatobiliary tumors. In: Withrow SJ, Vail DM, Page R,
Cordner AP, et al. Effect of pancreatic tissue sampling on serum eds. Withrow and MacEwen’s small animal clinical oncology. 5th
pancreatic enzyme levels in clinically healthy dogs. J Vet Diagn ed. St Louis: Saunders Elsevier; 2013:405.
Invest. 2010;22:702. Mansfield CS, et al. Association between canine pancreatic-specific
Forman MA, et al. Evaluation of serum feline pancreatic lipase lipase and histologic exocrine pancreatic inflammation in dogs:
immunoreactivity and helical computed tomography versus con- assessing specificity. J Vet Diagn Invest. 2012;24:312.
ventional testing for the diagnosis of feline pancreatitis. J Vet Marolf AJ, et al. Hepatic and pancreaticobiliary MRI and MR chol-
Intern Med. 2004;18:807. angiopancreatography with and without secretin stimulation in
Fry W, et al. Thromboelastography in dogs with chronic hepatopa- normal cats. Vet Radiol Ultrasound. 2011;52:415.
thies. J Vet Intern Med. 2017;31:419. Marolf AJ. Diagnostic imaging of the hepatobiliart system: an
Gallagher AE, et al. Hyperphosphatasemia in Scottish terriers: 7 update. Vet Clin North Am Small Anim Pract. 2017;47:555.
cases. J Vet Intern Med. 2006;20:418. Mayhew PD, et al. Evaluation of coagulation in dogs with partial
Gaskill CL, et al. Serum alkaline phosphatase isoenzyme profiles in or complete extrahepatic biliary obstruction by means of throm-
phenobarbital-treated epileptic dogs. Vet Clin Pathol. 2004;33:215. boelastography. J Am Vet Med Assoc. 2013;242:778.
Gerritzen-Bruning MJ, et al. Diagnostic value of fasting plasma McDevitt HL, et al. Short-term clinical outcome of laparoscopic
ammonia and bile acid concentrations in the identification of liver biopsy in dogs: 106 cases (2003-2013). J Am Vet Med Assoc.
portosystemic shunting in dogs. J Vet Intern Med. 2006;20:13. 2016;248:83.