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Risk Factors for Wearing-off Phenomenon in Idiopathic Parkinson's Disease

Tipakorn Tumnark MD., Natlada Limotai MD., Metha Apiwattanakul MD.

Prasat Neurological Institute, Department of Medical services,

Ministry of public Heath, Bangkok Thailand

Objectives: To study risk factors that associated with wearing off phenomenon

in Parkinson’s disease.

Methods: Retrospective study of patients who were valuated at Prasat

Neurological Institute abnormal movement clinic during January, 2013-August,

2014 and were diagnosed as idiopathic Parkinson’s disease was performed.

Patient characteristics, details of treatment and motor fluctuation

complications base on wearing off questionnaire 9 (WOQ 9) were corrected

and analyzed.

Results: A total of 90 patients were included in the study. Thirty eight (42.2%)

patients were women. Mean age was 60.6 years (36-84 years; SD 10.3). Mean

age at onset was 47.6 years (36-84 years; SD 19.3). Seventy three patients (81%)

developed complications, which were wearing off, from the complete WOQ 9

questionnaire the motor symptom were tremor (57%), slowness (54%),

reduced dexterity (39%),stiffness (40%) and muscle cramping (41%). The non-

motor symptom included cloudy/slow thinking (24.4%), pain (42.2%), mood

changes (27.8%) and anxiety (23.3%). Factors associated with wearing off

complications were earlier age of onset, long duration of disease, advanced

th
19 Annual Academic Meeting of Prasat Neurological Institute, 2015