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Factors Related to Depression in Epilepsy patients Who Have Taken

Levetiracetam Monotherapy

Theerawat Gomolplitinant MD, Kanjana Unnwongse MD

Prasat Neurological Institute, Department of Medical Services,

Ministry of Public Healh, Bangkok,Thailand

Objectives: A cohort study with 5 million participants showed higher incidence

of suicide-related event in patients with epilepsy, treated with antiepileptic

drugs (AEDs). Clinical trials indicated that newer AEDs increased risk of

depressive disorders for > 1% of treated patients. Almost 4% of levetiracetam

(LEV) (considered as high potential drug) treated patients experienced mood

instability as compared with < 1% of patients received other AEDs. Here we did

cross-sectional study to examine frequency of depression and features related

to depression in epileptic patients who took LEV monotherapy.

Materials and Methods: We enrolled 345 patients who were on LEV

monotherapy from 2,028 patients, followed up at our institute during 2013-

2014. Of these, 233 patients who aged 18-60 years old and have taken LEV at

250-1000 mg per day for at least 1 year are include in this analysis. We used

Hospital Anxiety and Depression Scale (HADs) for diagnosis of depression.

Factors associated with depression were then identified, using univariable and

multivariable analysis.

Results: Out of 233, 77 patients have depression based on HADs. In univariable

analysis, gender, marital status, financial tier, etiology and risk of epilepsy and

th
19 Annual Academic Meeting of Prasat Neurological Institute, 2015