Page 58 - Children Bookt.pdf
P. 58
Any child with active TB disease should begin TB treatment immediately, and start
ART as soon as tolerated(2 to 8 weeks of TB therapy) irrespective of the CD4 count
and clinical stage.
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is a triple NRTI regimen.
For all HIV-infected infants and children, who develop TB on ART anti-TB therapy
should be started immediately upon the diagnosis of TB; ART should continue.
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treatment
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Since rifampicin is known to reduce levels of NVP, do not use lead-in dosing of NVP
when initiating NVP-containing ART with TB treatment.
Rifampicin lowers the drug level of Nevirapine by 20 to 58% and that of EFV by 25%.
In children, there is no information on the appropriate dosage for NVP and EFV when
used with Rifampicin. Standard dosage of EFV can be used.
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2 NRTIs + EFV
OR
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After completion of Rifampicin based treatment, consider switching treatment to
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standard 1 line regimen 2NRTI+NVP or EFV.
50
