Page 59 - Children Bookt.pdf

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IRIS has been observed in children receiving anti-TB therapy who have initiated
ART. This syndrome is primarily reported in adults, but is also seen in children. A

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for diagnosis. Where available, an increase in CD4 count and a decrease in viral load
since start of ART would further support the diagnosis of IRIS. Some cases of IRIS in
HIV-infected children may in fact be TB. Other cases may be localized or disseminated
BCG disease in children who have received a BCG vaccination. HIV-infected children
suspected of having disseminated BCG disease should be referred to an appropriate

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Antecedent requirements }

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1. Diagnosis of TB in line with WHO recommendations
is made before starting ART
2. A good initial response to TB therapy is observed
before the patient started on ART

Clinical criteria The onset of TB-associated IRIS should be within
3 months of starting ART with at least one major

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