Page 442 - Essential Haematology

428 / Appendix 2 WHO classifi cation of tumours of the haematopoietic and lymphoid tissues

’
Myeloid proliferations related to Down s Plasma cell myeloma
syndrome Solitary plasmacytoma of bone
Transient abnormal myelopoiesis Extraosseous plasmacytoma
AML associated with Down ’ s syndrome Extranodal marginal zone B - cell lymphoma of
Blastic plasmacytoid dendritic cell neoplasm mucosa - associated lymphoid tissue (MALT
Acute leukaemias of ambiguous lineage lymphoma)
Acute undiff erentiated leukaemia Nodal marginal zone B - cell lymphoma
Acute biphenotypic leukaemia Paediatric type nodal marginal zone lymphoma
Follicular lymphoma
Precursor l ymphoid n eoplasms Paediatric type follicular lymphoma
Primary cutaneous follicle centre lymphoma
B - lymphoblastic leukaemia/lymphoma
Mantle cell lymphoma
B - lymphoblastic leukaemia/lymphoma, not
Diffuse large B - cell lymphoma (DLBCL), not

otherwise specifi ed
otherwise specifi ed
B - lymphoblastic leukaemia/lymphoma with
T - cell/histiocyte - rich large B - cell lymphoma
recurrent cytogenetic/molecular genetic
DLBCL associated with chronic infl ammation
abnormalities
Epstein – Barr virus (EBV) - positive DLBCL of
B - lymphoblastic leukaemia/lymphoma with t(9;
the elderly
22)(q34; q11.2), BCR – ABL1
Lymphomatoid granulomatosis
B - lymphoblastic leukaemia/lymphoma with
Primary mediastinal (thymic) large B - cell
t(11q23), MLL rearranged
lymphoma
B - lymphoblastic leukaemia/lymphoma with t(12;
Intravascular large B - cell lymphoma
21)(p13; q22), TEL – AML1 ( ETV6 – RUNX1 )
Primary cutaneous DLBCL, leg type
B - lymphoblastic leukaemia/lymphoma with
Anaplastic lymphoma kinase (ALK) positive large
hyperdiploidy
B - cell lymphoma
B - lymphoblastic leukaemia/lymphoma with
Plasmablastic lymphoma
hypodiploidy (hypodiploid ALL)
Primary eff usion lymphoma
B - lymphoblastic leukaemia/lymphoma with t(5;
Large B - cell lymphoma arising in HHV8 -
14)(q31; q32), IL3 – IGH
associated multicentric Castleman disease
B - lymphoblastic leukaemia/lymphoma with t(1;
Burkitt lymphoma
19)(q23; p13.3), E2A – PBX1 ( TCF3 – PBX1 )

B - cell lymphoma, unclassifiable, with features
T - lymphoblastic leukaemia/lymphoma
intermediate between DLBCL and Burkitt
lymphoma

Mature B - c ell n eoplasms
B - cell lymphoma, unclassifiable, with features

Chronic lymphocytic leukaemia/small intermediate between DLBCL and classic
lymphocytic lymphoma Hodgkin lymphoma
B - cell prolymphocytic leukaemia
Splenic marginal zone lymphoma Mature T - c ell and

Hairy cell leukaemia NK - c ell n eoplasms

Splenic lymphoma/leukaemia, unclassifi able
Splenic diffuse red pulp small B - cell lymphoma * T - cell prolymphocytic leukaemia

Hairy cell leukaemia variant * T - cell large granular lymphocytic leukaemia
Lymphoplasmacytic lymphoma Aggressive natural killer (NK) cell leukaemia
Waldenstr ö m ’ s macroglobulinaemia Systemic EBV - positive T - cell lymphoproliferative
Heavy - chain diseases disease of childhood (associated with chronic
α Heavy - chain disease active EBV infection)
γ Heavy - chain disease Hydroa vaccineforme - like lymphoma
μ Heavy - chain disease Adult T - cell leukaemia/lymphoma