Page 1217 - Basic _ Clinical Pharmacology ( PDFDrive )

Index 1203

tenoxicam, 649 Cyclosporine (cyclosporin A, CSA), 887 D
tolmetin, 644f, 645t, 649 antirheumatic actions of, 651 D 3 , for bone homeostasis, 789t
C-peptide, 747–748 drug interactions of, 1164t–1165t Dabigatran etexilate mesylate, 618
Cretinism, 691, 696t immunosuppressive uses of, 986 Dabrafenib, 975
Crisaborole, 1081–1082 CYP1A2, 62t, 66t Dacarbazine, 955t, 956
Crofelemer, 248t, 252t, 1099 CYP2A6, 66t Daclatasvir, 888
Crohn’s disease CYP3A4, 67t, 384 Daclizumab, 994
helper T cell type 1 dysregulation in, CYP3A5, 64f, 67t, 68 Daglutril, 312, 317t
1110 CYP2B6, 62t, 64f, 66t, 69 Dalbavancin, 803t, 809–810, 812t
treatment of, 1087, 1119 CYP2C8, 66t Dalteparin, 612–616. See also Heparin
Cromolyn, 281 CYP2C9, 62t, 64f, 66t, 68 Danazol, 738–739
allergic rhinoconjunctivitis treated with, characteristics of, 77t Dantrolene
356 polygenic effects in, 80t, 85–86 malignant hyperthermia treated with,
asthma treated with, 355–356, 360, 362t CYP2C18, 62t 449, 488
Crossover design, 14 CYP2C19, 62t, 64f, 66t, 68, 76t, 78, 79t spasmolytic actions of, 486f, 487–488,
Cross-tolerance, 565 CYP2CB, 62t 489t
Crotalidae polyvalent immune Fab antive- CYP2D6, 62t, 64f, 66t–67t, 67, 75–78, Dapagliflozin, 261–262, 272t, 274t, 763
nom, 1181t 76t, 79t Dapsone, 850, 1072
Crotamiton, 1075 CYP2E1, 62t Daptomycin, 803t, 810, 810f, 812t
Cryoablation, for cardiac arrhythmias, 246b Cyproheptadine, 282, 283t, 291 Daratumumab, 992
Cryoprecipitate, 623 Cyproterenone, 744 Darbepoetin alfa, 601, 602t, 606t
Cryptosporidium parvum, nitazoxanide for, Cyproterenone acetate, 744–745 Darbufelone, 332
933 Cysticercosis, 944 Darifenacin, 131, 135t. See also Muscarinic
C-type natriuretic peptide (CNP) Cystic fibrosis receptor blockers
description of, 308–309, 309f chloride channels in, 248b Darunavir, 871t, 880
on kidney, 259 heart and, 248b Dasabuvir, 889
Cumulative effects, 49 Cystic fibrosis transmembrane regulator Dasatinib, 967
Cushing’s syndrome, 710 (CFTR), 24, 30 Data, missing, 15
Cutaneous larva migrans. See also Cytarabine (ara-C), for immunosuppression, Datura, 125. See also Atropine; Muscarinic
Antihelminthic drugs 958t, 960, 989 receptor blockers
albendazole for, 939t, 940 Cytisine, 584, 588t Daunorubicin, 962t, 964–965
thiabendazole for, 946 Cytochrome P450-derived metabolites, DDT (chlorophenothane), 1010t,
Cyanide, 200, 1041t, 1044, 1044t 331–332 1010–1011, 1013f
Cyanocobalamin, 596, 598, 606t Cytochrome P450 oxidoreductase Deamination, 60t
Cyclic adenosine monophosphate (cAMP) (POR, CYP), 60t–61t Debrisoquin, 67, 181
in bronchodilation, 349, 350f Cytokine receptors, 28–29, 29f Debrisoquin-sparteine oxidation, 65
description of, 32, 34, 34f Cytokines, 996, 997t, 998 Dechlorination, 61t
Cyclic AMP response element binding Cytomegalovirus (CMV), 867–870 Decongestants, OTC
protein (CREB), 578 cidofovir for, 868t, 869 systemic, 1125t
Cyclic guanosine monophosphate (cGMP), foscarnet for, 868t, 869 topical, 1125t
34, 343f fundamentals of, 867 Decontamination
Cyclizine, 283t ganciclovir for, 868, 868t description of, 898t
Cyclobenzaprine, 488, 489t valganciclovir for, 868t, 868–869 of poisoned patient, 1039–1040
Cyclodienes, 1010t, 1010–1011, 1013f Cytomegalovirus immune globulin, 1180t Deep brain stimulation (DBS), 588
Cyclooxygenases, 322–323, 324f Cytopenia agents, 591–607 Deep sedation, 441b. See also Anesthetics,
Cyclopentolate, 130t, 135t. See also anemia agents, 591–600, 605t–607t general
Muscarinic receptor blockers hematopoietic growth factors, 600–605, Deep venous thrombosis (DVT)
Cyclophosphamide, 953f, 954. See also 606t from female hormonal contraceptives,
Alkylating agents preparations available, 607t 735
antirheumatic actions of, 650–651 Cytotoxic agents, immunosuppressive pulmonary embolism caused by, 608,
clinical activity of, 955t azathioprine, 988 625
immunosuppressive uses of, 988 cyclophosphamide, 988 thrombolytics for, 619
metabolism of, 954, 954f hydroxychloroquine, 989 Deferasirox, 596, 605t, 1032–1033
Cycloplegia, from atropine, 127, 128f methotrexate, vincristine, and cytarabine, Deferoxamine, 1032
Cycloserine 989 iron overload treated with, 596, 605t
description of, 811 pentostatin, 989 iron toxicity treated with, 596
tuberculosis treated with, 843t, 847 pyrimidine synthesis inhibitors, 988–989 Definitive therapy, antimicrobial, 905
Cyclospasm, 105b vinblastine, 989 Degarelix, 678–679