Page 1219 - Basic _ Clinical Pharmacology ( PDFDrive )

Index 1205

Desoxycorticosterone acetate, 709t. See also oral antidiabetic agents, 757–764, DiGeorge’s syndrome, 984
Corticosteroids, synthetic 768t–769t. See also Antidiabetic Digitalis, for heart failure, 217–219, 218t,
Destructive agents, dermatologic, 1083. agents, oral 219f
See also Keratolytic and destruc- type 1, 751–752 chronic, 223
tive agents type 2, 752 drug interactions of, 1165t
Desulfuration, 60t Diabetic ketoacidosis, 767 preparations available, 226t
Desvenlafaxine, 537, 546t, 550t. Diacetylmonoxime (DAM), 132 Digitalis antibody, for heart failure, 226t
See also Serotonin-norepinephrine Diacylglycerol (DAG), 32, 34, 34f, 138f, Digitalis glycosides, drug interactions of,
reuptake inhibitors (SNRIs) 139, 139t 1165t
Detemir, 768t. See also Insulin Dialysis, for poisoning, 1039t, 1040 Digoxin, 41, 55
Development and regulation, drug, 10–18 Diarrhea, 1100–1101, 1123t–1124t. drug interactions of, 1165t
breakthroughs in, 11 See also Antidiarrheal agents heart failure treated with, 223, 225t
drug discovery in, 11–13, 12f Diastereomers, 4, 4t mechanism of action of, 215
drug screening in, 12–13 Diastolic heart failure, 212, 223 in neonates, 1053t
human evaluation in, 14–18 Diastolic hypertension, 174 poisoning, 1041t, 1044–1045
adverse drug reactions in, 18 Diazepam, 393t. See also Benzodiazepines toxicity of, 223
clinical trials in acute ethanol withdrawal treated with, Digoxin immune fab, 223
confounding factors in, 14–15 406t Dihydroartemisinin, 922–923
IND & NDA, 15–17 in neonates, 1053t Dihydroartemisinin-piperaquine, 922, 922t
conflicts of interest in, 18 pharmacokinetics of, 385t, 450t Dihydrocodeine, 568. See also Opioid
Food & Drug Administration in, 15 seizures treated with, 432, 437t agonists
guidelines for, 14 spasmolytic actions of, 485, 489t Dihydroergotamine, 160
legislation on, 15, 16t structure of, 382f Dihydropyridines. See also Calcium channel
orphan drugs and rare diseases in, 18 Diazoxide, 186, 192t blockers; specific types
types of evidence in, 14b–15b Dibenzomethanes, 1076 angina pectoris treated with, 202–206,
new drug development in, 11, 12f Dibucaine number, 478 203t, 210t. See also Calcium
safety and toxicity testing in, preclinical, 2,4-Dichlorophenoxyacetic acid (2,4-D), channel blockers
13, 13t 1013f, 1013–1014 hypertension treated with, 179t, 187
Dexamethasone, 709t, 1105. See also Dichlorphenamide, 260t Dihydropyrimidine dehydrogenase (DPD,
Corticosteroids, synthetic Diclegis, 282, 296t. See also H 1 -receptor DPYD)
Dexamethasone suppression test, 711 antagonists deficiency of, 976
Dexfenfluramine, 289 Diclofenac. See also Nonsteroidal anti- pharmacogenomics of, 76t, 78, 79t, 81
Dexlansoprazole, 1091–1095. See also inflammatory drugs (NSAIDs) Dihydrotestosterone, synthesis of, 740
proton-pump inhibitors (PPIs) actinic keratoses treated with, 1084 Dihydroxyphenylalanine (DOPA), 495f
Dexmedetomidine. See also description of, 644f, 645t, 647 Dihydroxyphenylglycol (DHPG), 142
Sympathomimetics Dicumarol, 614f 1,25-Dihydroxyvitamin D (1,25[OH]2D),
anesthesia using, 450t, 457 Dicyclomine on bone homeostasis, 773, 774f
description of, 149, 153, 154t characteristics of, 135t Diiodotyrosine (DIT), 688, 688f
Dexrazoxane, 965 irritable bowel syndrome treated with, Diloxanide furoate, 929t, 930f, 930–931
Dextromethorphan, 570, 572t 1101 Diltiazem. See also Calcium channel
Diabetes insipidus structure of, 126f blockers
diuretics for, 272 Didanosine, 871t, 874–875 angina pectoris treated with, 202–206,
nephrogenic Diet 203t, 210t. See also Calcium
from ADH antagonists, 268–269 diabetes mellitus managed with, 764 channel blockers, angina pectoris
from lithium, 527 in drug metabolism, 70 treated with
Diabetes mellitus Dietary Supplement Health and Education arrhythmias treated with, 239t, 240t,
acute complications of, 767–768 Act (DSHEA), 1132 246, 251t
chronic complications of, 768 Dietary supplements, 3, 1141–1144 on double product, 208, 208f
complications of, 767–768 Diethylcarbazine citrate, 939t, 940–941 hypertension treated with, 179t, 187,
gestational, 752 Diethylstilbestrol, 723, 723f. See also 191t
hypoglycemia caused by, 767 Estrogen(s) Dimenhydrinate, 283t, 284, 1106
treatment of Difenoxin, 568. See also Opioid agonists Dimercaprol (2,3-dimercaptopropanol,
diet, 764 Diffusible second messengers, CNS, 369f, VAL), 1030, 1030f
education used in, 764–765 370 arsenic poisoning treated with, 1026
glycemic control, 765, 765b Diffusion lead poisoning treated with, 1024
insulin, 747–749, 768t. See also aqueous, 7–8, 8f mercury poisoning treated with, 1029
Insulin lipid, 8, 8f Dimercaptopropanesulfonic acid (DMPS),
nonpharmacologic, 764–765 Diflunisal, 645t, 647 1031–1032