Page 1218 - Basic _ Clinical Pharmacology ( PDFDrive )

1204 Index

Degree of spareness, 22f, 23 isotretinoin, 1077–1078 fluorouracil, 1083
Dehydroemetine, 929t, 931 retinoic acid derivatives, 1077 ingenol mebutate, 1083–1084
Dehydroepiandrosterone (DHEA), 740 antibacterial agents, topical NSAIDs, 1084
Dehydroepiandrosterone sulfate (DHEAS), bacitracin and gramicidin, 1070 podophyllum resin and podofilox,
740 fundamentals of, 1070 1083
Delavirdine, 871t, 877 mupirocin, 1070 propylene glycol, 1082
Delayed afterdepolarizations (DADs), 218, neomycin and gentamicin, 1071 salicylic acid, 1082
233, 233f polymyxin B sulfate, 1070–1071 sinecatechins, 1083
Delayed effects, 49 retapamulin, 1070 urea, 1082–1083
Delayed-type hypersensitivity (DTH), 983, antibacterial agents, topical acne melanoma agents, 1085
984f clindamycin, 1071 other agents, 1086t
Delirium tremens, 400 dapsone, 1072 percutaneous absorption in, 1068,
management of, 403 erythromycin, 1071 1069df
mortality rate for, 585 metronidazole, 1071 pharmacology response in, 1068
sedative-hypnotics for, 391 sodium sulfacetamide, 1071–1072 pigmentation agents, 1076–1077
Delta opioid receptors, 553, 554t antifungal agents, oral hydroquinone, monobenzone, and
Demeclocycline, 817 azole derivatives, 1073 mequinol, 1076
Dendrites, 368 griseofulvin, 1074 trioxsalen and methoxsalen, 1076
Denervation supersensitivity, 103 terbinafine, 1074 psoriasis drugs
Denileukin diftitox, 998 antifungal agents, topical acitretin, 1078
Denosumab, 995 allylamines, 1073 biologic agents, 1079
on bone homeostasis, 781 azole derivatives, 1072 fumaric acid esters, 1079
osteoporosis treated with, 775, 780b, butenafine, 1073 TNF inhibitors, 1079
787, 790t ciclopirox olamine, 1072 ustekinumab, 1079
Deoxycorticosterone (DOC), 714–715 nystatin and amphotericin B, 1073 calcipotriene and calcitriol,
Deoxycytidine analogs tolnaftate, 1073 1078–1079
cytarabine, 958t, 960 anti-inflammatory agents, 1079–1082 tazarotene, 1078
gemcitabine, 958t, 960 corticosteroids, topical, 1079–1081, sunscreens, 1076–1077
Dependence, physical, 389, 576–578 1080t, 1081t trichogenic and antitrichogenic agents
alcohol (ethanol), 396, 400 tar compounds, 1082 bimatoprost, 1085
benzodiazepine, 584 antineoplastic agents eflornithine, 1085
clinical pharmacology of, 587–588 alitretinoin, 1085 finasteride, 1085
definition of, 559, 575 bexarotene, 1085 minoxidil, 1084–1085
opioid, 559, 564–565, 566 romidepsin, 1085 Dermatologic vehicles, 1068–1070
sedative-hypnotics, 389–390 vismodegib, 1085 Desensitization, 32, 33f
on sedative-hypnotics, 391 vorinostat, 1085 of adrenoreceptors, 141
tolerance in, 576–578 antipruritic agents by G protein-coupled receptor kinases,
withdrawal, 576–578 doxepin, 1084 141
Depression pramoxine, 1084 heterologous, 141
acute bipolar, antipsychotics for, 519 antiseborrhea agents, 1084, 1084t homologous, 141
from female hormonal contraceptives, 735 antiviral agents, topical, 1074 membrane, by muscle relaxants, 479f,
major depressive disorder, 526, 532–536. dermatologic vehicles, 1068–1070 480
See also Major depressive disorder drug reactions, 1068, 1070t Desflurane, 441–449. See also Anesthetics,
(MDD) ectoparasiticides inhaled
pathophysiology of, 533–536 benzyl alcohol, 1076 properties of, 443t
integration of hypotheses on, 536 crotamiton, 1075 structure of, 443f
monoamine hypothesis in, 533, ivermectin, 1075 Design, rational drug, 4
534–536, 535f lindane, 1075 Desipramine, 537, 546t
neuroendocrine factors in, 536 malathion, 1076 Desloratadine, 281, 283t, 296t. See also
neurotrophic hypothesis in, 533f, permethrin, 1075 H 1 -receptor antagonists
533–534 spinosad, 1075 Desmethyldiazepam, 382f
recurrent, lithium for, 526 sulfur, 1075 Desmopressin
unipolar, antipsychotics for, 519 immunomodulators description of, 681–682, 684t
Dermatologic pharmacology, 1068–1086 imiquimod, 1074 diuresis using, 268
acne preparations tacrolimus and picrolimus, structure of, 681f
azelaic acid, 1078 1074–1075 Desmopressin acetate, 622, 622t
benzoyl peroxide, 1078 keratolytic and destructive agents Desogestrel, 728, 728t, 729f. See also
brimonidine, 1078 aminolevulinic acid, 1084 Progestins