Page 270 - Atlas of Histology with Functional Correlations

FIGURE 7.19 ■ Endochondral ossification: development of a long bone
(panoramic view, longitudinal section). Stain: hematoxylin and eosin. Low
magnification.

FIGURE 7.20 | Endochondral Ossification: Zone

of Ossification

This figure shows endochondral ossification at higher magnification and in

greater detail and corresponds to the upper region of Figure 7.19.

Proliferating chondrocytes (1, 14) are arranged in distinct vertical columns.
Below is the zone of hypertrophied chondrocytes (2, 15). Chondrocytes and
lacunae undergo hypertrophy as a result of increased glycogen and lipid

accumulations in their cytoplasm and nuclear swelling. The cytoplasm of
hypertrophied chondrocytes (2, 15) becomes vacuolized (16), the nuclei become
pyknotic, and the thin cartilage plates become surrounded by calcified matrix
(5, 17).

269