Page 648 - Atlas of Histology with Functional Correlations

gallbladder

Enteroendocrine cells in intestinal mucosa release cholecystokinin as fats in
chyme enter duodenum
Cholecystokinin causes gallbladder contraction and expulsion of bile
Bile emulsifies fats for more efficient digestion by pancreatic lipases
Fats are absorbed into lymphatic lacteals in the villi of small intestine

Hepatocytes excrete bilirubin into bile and move antibodies from blood into
bile

Endocrine Functions

Take up, metabolize, accumulate, and store products from blood
Synthesize and release most plasma proteins, including blood-clotting factors
Store glycogen and release as glucose when needed

Phagocytic Functions

Detoxify drugs and harmful substances that flow through sinusoids
Specialized liver macrophages, Kupffer cells, line the sinusoids

Kupffer cells filter and phagocytose debris and worn-out red blood cells

PANCREAS

Exocrine

Head of organ lies in the duodenal loop and tail extends to the spleen

Exocrine component forms majority of the organ and is composed of serous
acini
Acinar cells filled with granules that contain digestive enzymes
Acini contain pale-staining centroacinar cells in their lumina from which
excretory ducts start

Centroacinar cells continuous with cells of short intercalated ducts
Excretory ducts do not have striated cells, striated ducts, or myoepithelial
cells

Neural and hormones secretin and cholecystokinin regulate exocrine
secretions

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