Page 48 - Book of Invited & Keynotes Talks

th
8 Biannual Conference on Chemistry - CHEM 08

Synthetic Strategies to Novel Antimetabolites

Galal Elgemeie
Chemistry Department, Faculty of Science, Helwan University, Helwan,
Cairo, Egypt

ABSTRACT

Antimetabolites are drugs which are structurally similar to essential
metabolites, they may inhibit the synthesis of these metabolites and
biological pathways in which the natural occurring metabolites are

involved. The marketed antimetabolites are categorized as antifolates,
pyrimidine analogs and purine analogs. Research in my group involves the

design and synthesis of derivatives and analogs of the naturally occurring
metabolites.

References:

[1] G. Elgemeie et al. Tetrahedron, 50, 199 (1994), 73, 5853 (2017).
[2] G. Elgemeie Current Pharmaceutical Design, Bentham Science
Publishers, Exceutive Editor: G. Elgemeie, USA, 9 (31), 2627 (2003).
[3] G. Elgemeie et al. Eur. J. Med. Chem., 46, 229 (2011).
[4] G. Elgemeie et al. Drug Design, Development and Therapy, 11, 3389
(2017), 12,1785 (2018), 13, 2437 (2019).
[5] G. Elgemeie et al. ACS Omega, 5, 1640 (2020).

BOOK OF INVITED SPEAKERS & KEYNOTES CHEM 08 (2020) Page 48