Page 176 - Phytochemistry 2 (06-PG 605)
P. 176
The activity is inhibited on mild or strong alkalie
treatment.Mild alkalie affects stereochemistry of the lactone
ring, it cause epimerization at position α to the carbonyl,
results in the formation of more stable cis fused lactone
(inactive)
O cis-fused lactone ring(inactive
trans-fused lactone ring(active)
