Page 180 - Phytochemistry 2 (06-PG 605)
P. 180
Natural antitumor agents in clinical trials
i-Sesquiterpenes e.g. artemisinins
ii-Triterpenoids
1-Bruceolides:
Source: Brucea javanica and B. antidysentrica (Family
Simarubaceae)
Mechanism of antitumour activity: alkylating agent
Alkylation mechanism of DNA at nitrogen atom of guanine through
hydrogen bonding.
